ArticleThe Journal of clinical investigation1988
Isolation and characterization of expression cDNA clones encoding antigens of Onchocerca volvulus infective larvae.
Article in The Journal of clinical investigation, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 77 citations in OpenAlex.
- Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle WithFrontiers in cellular and infection microbiology · 2022Review
- Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection.PLoS neglected tropical diseases · 2016Article
- An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis.Molecular & cellular proteomics : MCP · 2015Article
- Nuclear hormone receptors in parasitic helminths.Molecular and cellular endocrinology · 2011Review
- Release of calreticulin from neutrophils may alter C1q-mediated immune functions.The Biochemical journal · 1997Article
- Human autoantibody to defensin: disease association with hyperreactive onchocerciasis (sowda).The Journal of experimental medicine · 1995Article
- Epitopes of the Onchocerca volvulus RAL1 antigen, a member of the calreticulin family of proteins, recognized by sera from patients with onchocerciasis.Infection and immunity · 1994Article
- Calreticulin: not just another calcium-binding protein.Molecular and cellular biochemistry · 1994Review
- How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.Molecular biology of the cell · 1994Review
- Covalent structure of bovine brain calreticulin.The Biochemical journal · 1994Article
- Onchocerca volvulus and Acanthocheilonema viteae: cloning of cDNAs for muscle-cell intermediate filaments.Parasitology research · 1994Article
- Structure and homology of human C1q receptor (collectin receptor).Immunology · 1993Article
- Calreticulin.The Biochemical journal · 1992Review
- Serological cross-reactivity between a human Ro/SS-A autoantigen (calreticulin) and the lambda Ral-1 antigen of Onchocerca volvulus.The Journal of clinical investigation · 1992Article
- Structural homology between the rat calreticulin gene product and the Onchocerca volvulus antigen Ral-1.Nucleic acids research · 1990Article
- A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule".The Journal of clinical investigation · 1990Article
- Cytokine regulation of antigen-driven immunoglobulin production in filarial parasite infections in humans.The Journal of clinical investigation · 1990Article
- Many transcribed regions of the Onchocerca volvulus genome contain the spliced leader sequence of Caenorhabditis elegans.Molecular and cellular biology · 1990Article
- Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.The Journal of clinical investigation · 1990Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The isolation of recombinant cDNA clones expressing antigens found in Onchocerca volvulus infective larvae is described. To isolate such clones, an expression cDNA library constructed from adult O. volvulus RNA was screened with antiserum raised against infective larvae. One clone, designated lambda RAL-1 was characterized further. The recombinant antigen produced by lambda RAL-1 stimulates proliferation of peripheral blood mononuclear cells from O. volvulus infected humans. Lambda RAL-1 is derived from a 1450 bases message that encodes a protein with an apparent molecular weight of 42,000 in adult O. volvulus. The inserted DNA of lambda RAL-1 contains an open reading frame of 1008 bp. The amino acid sequence predicted by this open reading frame contains three repeats of the sequence KKPEDWD. The identification of clones such as lambda RAL-1 will provide quantities of purified antigens sufficient to begin to study the immune response to and explore the development of immunity against the infectious form of the parasite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.