ArticleAnesthesia and analgesia2014
The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol.
Article in Anesthesia and analgesia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Identification and quantification of two etomidate analogues ABP-700 and 2,6-dichloro-3-fluoro-etomidate in e-cigarette liquid and hair by GC-MS and LC-MS/MS.Forensic toxicology · 2026Article
- Chiral analysis of etomidate and metomidate enantiomers in hair by UHPLC-MS/MS: application to authentic human hair samples and enantiomeric fraction assessment.International journal of legal medicine · 2026Article
- Identification of two novel imidazole-derived GABA agonists butomidate and tf-etomidate in e-cigarette liquids.Forensic toxicology · 2026Article
- Identification of a novel imidazole-derived GABA agonist isopropoxate: simultaneous detection and quantification of imidazole-derived analogs from human hairs in abused cases by LC-MS/MS.Forensic toxicology · 2025Article
- How to trace etomidate in illegal E-cigarettes from authentic human hair: identification, quantification and multiple-factor analysis.Forensic toxicology · 2025Article
- Review
- Detection and quantification of etomidate and metomidate in human hairs by ultraperformance liquid chromatography with triple quadrupole mass spectrometry (UPLC-MS/MS).Forensic toxicology · 2024Article
- Article
- Etomidate and its Analogs: A Review of Pharmacokinetics and Pharmacodynamics.Clinical pharmacokinetics · 2021Review
- Anesthetic pretreatment confers thermotolerance on Saccharomyces cerevisiae yeast.Biochemical and biophysical research communications · 2020Article
- Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy.Anesthesiology · 2017Article
- The Role of GABA Receptor Agonists in Anesthesia and Sedation.CNS drugs · 2017Review
- Sedative-hypnotic Binding to 11β-hydroxylase.Anesthesiology · 2016Article
- Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite.Anesthesia and analgesia · 2016Article
- γ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs.Anesthesiology · 2016Article
- Effects of Using Tricaine Methanesulfonate and Metomidate before Euthanasia on the Contractile Properties of Rainbow Trout (Oncorhynchus mykiss) Myocardium.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.The Journal of physiology · 2015Article
- Etomidate derivatives: Novel pharmaceutical agents in anesthesia.Journal of anaesthesiology, clinical pharmacologyReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCyclopropyl-methoxycarbonyl metomidate (CPMM) is a "soft" etomidate analogue currently being developed as a propofol alternative for anesthetic induction and maintenance.
methodsWe compared the potencies of CPMM and propofol by assessing their abilities to directly activate α1(L264T)β3γ2 gamma-aminobutyric acid type A (GABAA) receptors and induce loss of righting reflexes in tadpoles. We also measured the rates of encephalographic recovery in rats after CPMM and propofol infusions ranging in duration from 5 to 120 minutes.
resultsCPMM and propofol activate GABAA receptors and induce loss of righting reflexes in tadpoles with respective 50% effective concentrations (EC50s) of 3.8 ± 0.4 and 3.9 ± 0.2 μM (GABAA receptor) and 2.6 ± 0.19 and 1.3 ± 0.04 μM (tadpole). Encephalographic recovery after prolonged infusion was faster with CPMM and lacked propofol's context sensitivity.
conclusionCPMM and propofol have similar potencies in GABAA receptors and tadpoles; however, CPMM provides more rapid and predictable recovery than propofol, particularly after prolonged infusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.