ArticlePsychopharmacology2014
Amplified reacquisition of nicotine self-administration in rats by repeated stress during abstinence.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Review
- Neurobiology of Stress-Induced Nicotine Relapse.International journal of molecular sciences · 2024Review
- The reinforcement threshold and elasticity of demand for nicotine in an adolescent rat model of depression.Drug and alcohol dependence · 2021Article
- Smoking and stress in the general population in Denmark.Tobacco prevention & cessation · 2021Article
- Allosteric Modulation of GABAACS pharmacology & translational science · 2020Article
- A potential role for microglia in stress- and drug-induced plasticity in the nucleus accumbens: A mechanism for stress-induced vulnerability to substance use disorder.Neuroscience and biobehavioral reviews · 2019Review
- Cerebrovascular Injury After Serial Exposure to Chronic Stress and Abstinence from Methamphetamine Self-Administration.Scientific reports · 2018Article
- Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction.Translational psychiatry · 2017Review
- Basolateral amygdala and ventral hippocampus in stress-induced amplification of nicotine self-administration during reacquisition in rat.Psychopharmacology · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
rationaleQuitting smoking is often very challenging, leading to frequent relapse. Exposure to acute and chronic stress during abstinence increases the likelihood of relapse to smoking. In rodents, stress acutely reinstates nicotine seeking after extinction of nicotine self-administration (SA). However, whether reacquisition of nicotine taking is amplified by chronic stress during abstinence from nicotine SA has not been determined in animals.
objectivesWe sought to determine effects of repeated restraint stress during abstinence on reacquisition of nicotine SA.
methodsRats acquired nicotine SA (23 h/day) under a fixed-ratio (FR) 5 schedule of reinforcement, which was followed by an abstinence phase. Restraint (0, 2, and 4 times) was administered during abstinence. Animals reacquired nicotine SA, first under a progressive ratio (PR) schedule, beginning immediately after the final stress, followed by an FR5 schedule. In another experiment, reacquisition (FR5) began 24 h after the final stress. No PR testing was conducted.
resultsFour restraint stress exposures during abstinence, but not only two, enhanced reacquisition of nicotine SA by increasing nicotine injections under a PR schedule beginning immediately after the final stress (p < 0.05) followed by increasing nicotine intake under an FR5 schedule (p < 0.05). This was observed even when the final stress and reacquisition trial were separated by 24 h. Moreover, repeated stress-induced nicotine taking during the behaviorally inactive phase (i.e., lights on) of the 24-h diurnal cycle.
conclusionsChronic (i.e., repeated) stress during abstinence promotes reacquisition of nicotine SA and affects diurnal pattern of nicotine intake.
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