Evidence map›Paper›PMID 24557009›Full record

Trial reportDigestion2014

A randomized controlled trial of mindfulness-based stress reduction to prevent flare-up in patients with inactive ulcerative colitis.

S Jedel, A Hoffman, P Merriman, B Swanson, R Voigt, K B Rajan, M Shaikh, H Li, A Keshavarzian

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Digestion, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03664128 (Pregnancy and Anxious Thoughts), which is not on this map. Cited by 57 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 11 pooled it
10.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03664128 completednot on this mapstarted 2016, after this paper: background citation

Pregnancy and Anxious Thoughts: The Role of the Immune and Endocrine Systems

TypeobservationalSponsorJohns Hopkins UniversityRan2016 to 2022Enrolled157ConditionsPerinatal AnxietyArmsCoping with Anxiety through Living Mindfully (CALM) Pregnancy
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 11 syntheses or guidelines pooled it, 144 citations in OpenAlex.

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  2. Psychological interventions for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

S JedelDivision of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Ill., USA.
A Hoffman
P Merriman
B Swanson
R Voigt
K B Rajan
M Shaikh
H Li
A Keshavarzian
Rush University · USCancer Research And Biostatistics · USUniversity of Chicago · US

Funding

Mindfulness, Stress, and IBD Flare-UpR21AT003939 · NCCIH · RUSH UNIVERSITY MEDICAL CENTER · PI KESHAVARZIAN, ALI · 2008 to 2010
$590k
NCCIH NIH HHS 5R21AT003939-02NCCIH NIH HHS R21 AT003939
6 · The paper itself

Abstract

BACKGROUND/

aimsThe primary therapeutic goals in ulcerative colitis (UC) are to maintain excellent quality of life (QOL) by treating flare-ups when they occur, and preventing flare-ups. Since stress can trigger UC flare-ups, we investigated the efficacy of mindfulness-based stress reduction (MBSR) to reduce flare-ups and improve QOL.

methodsPatients with moderately severe UC, in remission, were randomized to MBSR or time/attention control. Primary outcome was disease status. Secondary outcomes were changes in markers of inflammation and disease activity, markers of stress and psychological assessments.

results55 subjects were randomized. Absence of flares, time to flare and severity of flare over 1 year were similar between the two groups. However, post hoc analysis showed that MBSR decreased the proportion of participants with at least one flare-up among those with top tertile urinary cortisol and baseline perceived stress (30 vs. 70%; p < 0.001). MBSR patients who flared demonstrated significantly lower stress at the last visit compared to flared patients in the control group (p = 0.04). Furthermore, MBSR prevented a drop in the Inflammatory Bowel Disease Quality of Life Questionnaire during flare (p < 0.01).

conclusionMBSR did not affect the rate or severity of flare-ups in UC patients in remission. However, MBSR might be effective for those with high stress reactivity (high perceived stress and urinary cortisol) during remission. MBSR appears to improve QOL in UC patients by minimizing the negative impact of flare-ups on QOL. Further studies are needed to identify a subset of patients for whom MBSR could alter disease course.

Indexed as

MindfulnessQuality of LifeAdultAttentionColitis, UlcerativeC-Reactive ProteinDisease-Free SurvivalDisease ProgressionDouble-Blind MethodFecesFemaleHumansHydrocortisoneInterleukinsLeukocyte L1 Antigen ComplexMaleC-Reactive ProteinHydrocortisoneInterleukinsLeukocyte L1 Antigen Complex

Identifiers

PMID24557009
PMCPMC4059005
OpenAlexW1485424371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.