ArticleJournal of perinatology : official journal of the California Perinatal Association2014
Abnormal heart rate characteristics are associated with abnormal neuroimaging and outcomes in extremely low birth weight infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review.Neonatology · 2023Pooled it
- Prediction of intraventricular haemorrhage in preterm infants using time series analysis of blood pressure and respiratory signals.Scientific reports · 2017Trial
- The developing relationship between circadian rhythm and heart rate variability in premature infants.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Predicting Dexamethasone-Associated Extubation Success in Preterm Infants.American journal of perinatology · 2026Article
- Reduced heart rate variability predicts severe intraventricular haemorrhage in extremely preterm infants.Pediatric research · 2026Article
- Depressed heart rate variability predicts adverse neonatal events and outcomes, with important caveats.Pediatric research · 2026Article
- Quantitative measures of autonomic cardiorespiratory maturation in preterm infants are associated with brain volumes at term age.Early human development · 2026Article
- Using heart rate variability to predict neurological outcomes in preterm infants: a scoping review.Pediatric research · 2025Article
- Heart rate patterns predicting cerebral palsy in preterm infants.Pediatric research · 2025Article
- Sample entropy correlates with intraventricular hemorrhage and mortality in premature infants early in life.Pediatric research · 2024Article
- Heart rate characteristics predict risk of mortality in preterm infants in low and high target oxygen saturation ranges.ERJ open research · 2024Article
- Heart Rate and Pulse Oximetry Dynamics in the First Week after Birth in Neonatal Intensive Care Unit Patients and the Risk of Cerebral Palsy.American journal of perinatology · 2024Article
- Inflammatory biomarkers and physiomarkers of late-onset sepsis and necrotizing enterocolitis in premature infants.Frontiers in pediatrics · 2024Article
- Artificial and human intelligence for early identification of neonatal sepsis.Pediatric research · 2023Review
- Omics approaches: interactions at the maternal-fetal interface and origins of child health and disease.Pediatric research · 2023Review
- Vital signs as physiomarkers of neonatal sepsis.Pediatric research · 2022Review
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
- Precision Medicine in Neonates: A Tailored Approach to Neonatal Brain Injury.Frontiers in pediatrics · 2021Review
- Machine Learning-Based Automatic Classification of Video Recorded Neonatal Manipulations and Associated Physiological Parameters: A Feasibility Study.Children (Basel, Switzerland) · 2020Article
- Continuous vital sign analysis for predicting and preventing neonatal diseases in the twenty-first century: big data to the forefront.Pediatric research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveBrain injury in preterm infants may lead to an inflammatory response and central nervous system dysfunction reflected by abnormal heart rate characteristics (HRC). We hypothesized that a continuously monitored HRC index reflecting reduced HR variability and decelerations correlates with abnormal neuroimaging and outcomes in extremely low birth weight infants (ELBW). STUDY
designWe analyzed the average HRC index within 28 days after birth (aHRC28) and head ultrasound (HUS) in 384 ELBW infants. In 50 infants with brain magnetic resonance imaging (MRI) and 70 infants with Bayley neurodevelopmental testing at 1 year of age, we analyzed the relationship between aHRC28, MRI abnormalities and low Bayley scores.
resultaHRC28 was higher in infants with severe HUS abnormalities (2.65±1.27 for Grade III-IV intraventricular hemorrhage (IVH) or cystic periventricular leukomalacia (cPVL) versus 1.72±0.95 for normal or Grade I-II IVH, P<0.001). Higher aHRC28 was also associated with white matter damage on MRI and death or Bayley motor or mental developmental index <70. Associations persisted after adjusting for gestational age, birth weight and septicemia. For every one point increase in aHRC28, the odds ratio of death or Bayley score <70 was 2.45 (95% CI 1.46, 4.05, P<0.001).
conclusionA continuously monitored HRC index provides an objective, noninvasive measure associated with abnormal brain imaging and adverse neurologic outcomes in ELBW infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.