ArticleDementia and geriatric cognitive disorders2014
Emergence of mild cognitive impairment in late middle-aged adults in the wisconsin registry for Alzheimer's prevention.
Article in Dementia and geriatric cognitive disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 92 citations in OpenAlex.
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- Development of language composites for enhanced sensitivity to multiple plasma biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Abnormal Amyloid-β Duration, Tau, and Neurodegeneration in Cranial Images.JAMA network open · 2025Article
- Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle-Aged Offspring of People With Alzheimer's Disease.International journal of geriatric psychiatry · 2025Article
- Sex modifies the association between cardiorespiratory fitness and insulin resistance in adults at risk for Alzheimer's disease.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2025Observational
- Robust reference group normative data for neuropsychological tests accounting for primary language use in Asian American older adults.Journal of the International Neuropsychological Society : JINS · 2024Article
- Longitudinal normative standards for cognitive tests and composites using harmonized data from two Wisconsin AD-risk-enriched cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Predictors and outcomes of fluctuations in the clinical dementia rating scale.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late-onset dementia due to Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Comparison of the 10-, 14- and 20-Item CES-D Scores as Predictors of Cognitive Decline.Brain sciences · 2023Article
- Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status.Alzheimer's research & therapy · 2023Article
- Cross-sectional associations of CSF tau levels with Rey's AVLT: A recency ratio study.Neuropsychology · 2023Article
- DementiaBank: Theoretical Rationale, Protocol, and Illustrative Analyses.American journal of speech-language pathology · 2023Article
- Harnessing cognitive trajectory clusterings to examine subclinical decline risk factors.Brain communications · 2023Article
- Reference Data for Attentional, Executive, Linguistic, and Visual Processing Tests Obtained from Cognitively Healthy Individuals with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels.Journal of Alzheimer's disease : JAD · 2023Article
- Insulin Homeostasis Mediates the Relationship Between Cardiorespiratory Fitness and Cognitive Speed in Aging Adults.Journal of Alzheimer's disease : JAD · 2023Observational
- Plasma phosphorylated tau 217 in preclinical Alzheimer's disease.Brain communications · 2023Article
- Associations between self-reported sleep patterns and health, cognition and amyloid measures: results from the Wisconsin Registry for Alzheimer's Prevention.Brain communications · 2023Article
- Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer's disease.Aging brain · 2022Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
aimIt is difficult to reliably detect the earliest signs of Alzheimer's disease (AD)-associated cognitive impairment. Our aim was to compare 3 psychometric methods of identifying amnestic mild cognitive impairment (aMCI) in a middle-aged longitudinal cohort enriched for AD risk.
methodsWisconsin Registry for Alzheimer's Prevention (WRAP) participants with 3 waves of cognitive assessment over approximately 6 years were coded as meeting each of 3 psychometric aMCI definitions: (a) 'aMCI standard-baseline' used published norms to establish cutoffs for baseline performance; (b) 'aMCI robust-baseline' applied WRAP-specific robust norms to baseline, and (c) 'aMCI robust-multiwave' applied these robust norms across 3 waves of assessment. Each group was compared to a cognitively healthy subset.
resultsHalf the aMCI standard-baseline and one third of the aMCI robust-baseline group reverted to normal ranges at follow-up. Only the aMCI robust-multiwave method had an aMCI × age interaction showing significantly worse age-related memory declines in the aMCI group compared to the cognitively healthy group over 6 years of follow-up.
conclusionBoth cross-sectional methods showed instability over time, with many reverting to normal performance after baseline. The multiwave approach identified a group who showed progressive memory declines over 3 visits. Being able to detect progressive decline in late middle age is a critical step in improving prevention efforts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.