Trial reportJournal of pediatric gastroenterology and nutrition2014
Enhanced feeding and diminished postnatal growth failure in very-low-birth-weight infants.
Trial report in Journal of pediatric gastroenterology and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02478086 (Effects of High vs. Standard Protein Intake in the Weight Gain and Renal Function Security in Newborn Extreme Premature), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of High vs. Standard Protein Intake in the Weight Gain and Renal Function Security in Newborn Extreme Premature
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- High protein intake on later outcomes in preterm children: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Higher versus lower amino acid intake in parenteral nutrition for newborn infants.The Cochrane database of systematic reviews · 2018Pooled it
- Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy.The Cochrane database of systematic reviews · 2016Pooled it
- Plasma ammonia concentrations in extremely low birthweight infants in the first week after birth: secondary analysis from the ProVIDe randomized clinical trial.Pediatric research · 2020Trial
- Enhanced nutrient supply and intestinal microbiota development in very low birth weight infants.Pediatric research · 2019Trial
- Intestinal microbiota development and gestational age in preterm neonates.Scientific reports · 2018Trial
- Urinary metabolite profiles in premature infants show early postnatal metabolic adaptation and maturation.Nutrients · 2014Trial
- Postnatal Growth Assessment of the Very-Low-Birth-Weight Preterm Infant.Children (Basel, Switzerland) · 2025Review
- Targeting optimal protein delivery in parenteral and enteral nutrition for preterm infants: a review of randomized, controlled trials.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Postnatal growth and body composition in extremely low birth weight infants fed with individually adjusted fortified human milk: a cohort study.European journal of pediatrics · 2023Article
- Growth of a cohort of very low birth weight and preterm infants born at a single tertiary health care center in South Africa.Frontiers in pediatrics · 2022Article
- Effects of nutrition therapy on growth, inflammation and metabolism in immature infants: a study protocol of a double-blind randomized controlled trial (ImNuT).BMC pediatrics · 2021Article
- Neonatal Refeeding Syndrome and Clinical Outcome in Extremely Low-Birth-Weight Babies: Secondary Cohort Analysis From the ProVIDe Trial.JPEN. Journal of parenteral and enteral nutrition · 2021Article
- ELBW infants receive inadvertent sodium load above the recommended intake.Pediatric research · 2020Observational
- Article
- Accuracy of preterm infant weight gain velocity calculations vary depending on method used and infant age at time of measurement.Pediatric research · 2019Article
- Improving extrauterine growth: evaluation of an optimized, standardized neonatal parenteral nutrition protocol.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Observational
- Once small always small? To what extent morphometric characteristics and post-weaning starter regime affect pig lifetime growth performance.Porcine health management · 2018Article
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the present study was to determine whether an increased supply of energy, protein, essential fatty acids, and vitamin A reduces postnatal growth failure in very-low-birth-weight infants.
methodsFifty infants with birth weight <1500 g were randomized to an intervention (n = 24) or a control (n = 26) feeding protocol within 24 hours after birth. Forty-four infants were included in the final analysis. This study was discontinued because of an increased occurrence of septicemia in the intervention group.
resultsThe intervention group had a lower mean birth weight (P = 0.03) and a higher proportion of infants small-for-gestational age (P = 0.04) than the control group. Other baseline characteristics were similar. The median (interquartile range) energy and protein supplies during the first 4 weeks of life were higher in the intervention group: 139 (128-145) versus 126 (121-128) kcal · kg · day (P < 0.001) and 4.0 (3.9-4.2) versus 3.2 (3.1-3.3) g · kg · day (P < 0.001). The infants in the intervention group regained birth weight faster (P = 0.001) and maintained their z scores for weight and head circumference from birth to 36 weeks' postmenstrual age (both P < 0.001). The median (interquartile range) growth velocity was 17.4 (16.3-18.6) g · kg · day in the intervention group and 13.8 (13.2-15.5) g · kg · day in the control group (P < 0.001). In line with the improved growth in the intervention group, the proportion of growth-restricted infants was 11 of 23 both at birth and at 36 weeks' postmenstrual age, whereas this proportion increased among the controls from 4 of 21 to 13 of 21 (P = 0.04).
conclusionsEnhanced supply of energy, protein, essential fatty acids, and vitamin A caused postnatal growth along the birth percentiles for both weight and head circumference.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.