ArticleCaries research2014
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
Article in Caries research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Gene sequencing applications to combat oral-cavity related disorders: a systematic review with meta-analysis.BMC oral health · 2024Pooled it
- Pooled it
- Quantifying variations associated with dental caries reveals disparity in effect allele frequencies across diverse populations.BMC genomic data · 2024Article
- Evaluation of the effect of high-intensity light-curing device on micro-leakage of pits and fissure sealants.Lasers in medical science · 2023Article
- Bacterial Community Modifies Host Genetics Effect on Early Childhood Caries.Journal of dental research · 2023Article
- Bacterial community modifies host genetics effect on early childhood caries.medRxiv : the preprint server for health sciences · 2023Article
- Case Report: Treatment and management of a child at high risk of caries.Frontiers in pediatrics · 2023Article
- Fluoride in the drinking water and dental caries experience by tooth surface susceptibility among adults.BMC oral health · 2021Article
- Cohort Profile: ZOE 2.0-A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health.International journal of environmental research and public health · 2020Article
- Gene-Based Association Mapping for Dental Caries in The GENEVA Consortium.Journal of dentistry and dental medicine · 2020Article
- Genomics of periodontal disease and tooth morbidity.Periodontology 2000 · 2020Review
- The Era of the Genome and Dental Medicine.Journal of dental research · 2019Review
- Protocols, Methods, and Tools for Genome-Wide Association Studies (GWAS) of Dental Traits.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Genetic susceptibility to infectious diseases: Current status and future perspectives from genome-wide approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Review
- Consortium-based genome-wide meta-analysis for childhood dental caries traits.Human molecular genetics · 2018Article
- Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries.Journal of human genetics · 2017Article
- Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL).Human molecular genetics · 2016Article
- Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis).International journal of molecular medicine · 2015Review
- Improving children's oral health: an interdisciplinary research framework.Journal of dental research · 2014Article
- Clinical application of genetics to guide prevention and treatment of oral diseases.Clinical genetics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Dental caries continues to be the most common chronic disease in children today. Despite the substantial involvement of genetics in the process of caries development, the specific genes contributing to dental caries remain largely unknown. We performed separate genome-wide association studies of smooth and pit-and-fissure tooth surface caries experience in the primary dentitions of self-reported white children in two samples from Iowa and rural Appalachia. In total, 1,006 children (ages 3-12 years) were included for smooth surface analysis, and 979 children (ages 4-14 years) for pit-and-fissure surface analysis. Associations were tested for more than 1.2 million single nucleotide polymorphisms, either genotyped or imputed. We detected genome-wide significant signals in KPNA4 (p value = 2.0E-9), and suggestive signals in ITGAL (p value = 2.1E-7) and PLUNC family genes (p value = 2.0E-6), thus nominating these novel loci as putative caries susceptibility genes. We also replicated associations observed in previous studies for MPPED2 (p value = 6.9E-6), AJAP1 (p value = 1.6E-6) and RPS6KA2 (p value = 7.3E-6). Replication of these associations in additional samples, as well as experimental studies to determine the biological functions of associated genetic variants, are warranted. Ultimately, efforts such as this may lead to a better understanding of caries etiology, and could eventually facilitate the development of new interventions and preventive measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.