ReviewCurrent opinion in immunology2014
The central role of antigen presentation in islets of Langerhans in autoimmune diabetes.
Review in Current opinion in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes.Cell communication and signaling : CCS · 2025Article
- WDFY4 deficiency in NOD mice ameliorates autoimmune diabetes and insulitis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Tolerogenic dendritic cells in type 1 diabetes: no longer a concept.Frontiers in immunology · 2023Review
- Sustained high glucose intake accelerates type 1 diabetes in NOD mice.Frontiers in endocrinology · 2022Article
- In vitro platform establishes antigen-specific CD8Biomaterials · 2020Article
- Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes.The Journal of experimental medicine · 2020Article
- A Novel Quantitative Approach to Staging and Assessing Recovery from Type 1 Diabetes Mellitus: The Type 1 Diabetes Mellitus Metabolic Recovery Index.International journal of molecular sciences · 2020Article
- Emerging Roles of Exosomes in T1DM.Frontiers in immunology · 2020Review
- Extracellular Vesicles in Type 1 Diabetes: Messengers and Regulators.Current diabetes reports · 2019Review
- Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.Cell metabolism · 2019Article
- Class II MHC antigen processing in immune tolerance and inflammation.Immunogenetics · 2019Review
- CD11cFrontiers in immunology · 2019Article
- Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization.Journal of materials science. Materials in medicine · 2017Article
- Durable Control of Autoimmune Diabetes in Mice Achieved by Intraperitoneal Transplantation of "Neo-Islets," Three-Dimensional Aggregates of Allogeneic Islet and "Mesenchymal Stem Cells".Stem cells translational medicine · 2017Article
- Macrophages and dendritic cells in islets of Langerhans in diabetic autoimmunity: a lesson on cell interactions in a mini-organ.Current opinion in immunology · 2016Review
- The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.Immunological reviews · 2016Review
- Antigen presentation events during the initiation of autoimmune diabetes in the NOD mouse.Journal of autoimmunity · 2016Review
- Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair.eLife · 2016Article
- Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen.Immunological reviews · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The islets of Langerhans normally contain resident antigen presenting cells (APCs), which in normal conditions are mostly represented by macrophages, with a few dendritic cells (DC). We present here the features of these islet APCs, making the point that they have a supportive function in islet homeostasis. Islet APCs express high levels of major histocompatibility complexes (MHC) molecules on their surfaces and are highly active in antigen presentation in the autoimmune diabetes of the NOD mouse: they do this by presenting peptides derived from molecules of the β-cells. These APCs also are instrumental in the localization of diabetogenic T cells into islets. The islet APC present exogenous peptides derived from secretory granules of the β-cell, giving rise to unique peptide-MHC complexes (pMHC) that activate those non-conventional T cells that bypass thymus selection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.