Evidence map›Paper›PMID 24556253›Full record

ArticleComparative biochemistry and physiology. Toxicology & pharmacology : CBP2014

UVB-induced gene expression in the skin of Xiphophorus maculatus Jp 163 B.

Kuan Yang, Mikki Boswell, Dylan J Walter, Kevin P Downs, Kimberly Gaston-Pravia, Tzintzuni Garcia, Yingjia Shen, David L Mitchell, Ronald B Walter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Fluorescent light exposure incites acute and prolonged immune responses in zebrafish (Danio rerio) skin.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2018
    Article
  4. Exposure to 4100K fluorescent light elicits sex specific transcriptional responses in Xiphophorus maculatus skin.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2018
    Article
  5. Article
  6. Characterization of basal gene expression trends over a diurnal cycle in Xiphophorus maculatus skin, brain and liver.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2018
    Article
  7. Article
  8. Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015
    Article
  9. Sex-specific molecular genetic response to UVB exposure in Xiphophorus maculatus skin.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015
    Article
  10. Molecular genetic response to varied wavelengths of light in Xiphophorus maculatus skin.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015
    Article
  11. Molecular genetic response of Xiphophorus maculatus-X. couchianus interspecies hybrid skin to UVB exposure.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kuan YangMolecular Biosciences Research Group, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, United States. Electronic address: k_y18@txstate.edu.
Mikki BoswellMolecular Biosciences Research Group, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, United States. Electronic address: mboswell@txstate.edu.
Dylan J WalterMolecular Biosciences Research Group, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, United States. Electronic address: djw3@txstate.edu.
Kevin P DownsMolecular Biosciences Research Group, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, United States. Electronic address: kd1186@txstate.edu.
Kimberly Gaston-PraviaMolecular Biosciences Research Group, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, United States. Electronic address: kg1217@txstate.edu.
Tzintzuni GarciaMolecular Biosciences Research Group, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, United States. Electronic address: tg23@txstate.edu.
Yingjia ShenMolecular Biosciences Research Group, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, United States. Electronic address: ys14@txstate.edu.
David L MitchellDepartment of Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX, United States. Electronic address: dmitchel@mdanderson.org.
Ronald B WalterMolecular Biosciences Research Group, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, United States. Electronic address: RWalter@txstate.edu.
Texas State University · USThe University of Texas MD Anderson Cancer Center · US

Funding

Enhanced Development of the Xiphophorus Model System R24-OD-011120R24OD011120 · OD · TEXAS STATE UNIVERSITY · PI GABOR, CAITLIN, LU, YUAN · 2012 to 2019
$5.3M
Advancing the Scientific Potential of Transcriptomics in Aquatic ModelsR24OD011199 · OD · UNIVERSITY OF OREGON · PI CRESKO, WILLIAM A, POSTLETHWAIT, JOHN H. · 2012 to 2014
$1.8M
NIH HHS R24 OD011120NIH HHS R24-OD-011120NIH HHS R24 OD011199NIH HHS R24-OD-011199
6 · The paper itself

Abstract

Xiphophorus fish and interspecies hybrids represent long-standing models to study the genetics underlying spontaneous and induced tumorigenesis. The recent release of the Xiphophorus maculatus genome sequence will allow global genetic regulation studies of genes involved in the inherited susceptibility to UVB-induced melanoma within select backcross hybrids. As a first step toward this goal, we report results of an RNA-Seq approach to identify genes and pathways showing modulated transcription within the skin of X. maculatus Jp 163 B upon UVB exposure. X. maculatus Jp 163 B were exposed to various doses of UVB followed by RNA-Seq analysis at each dose to investigate overall gene expression in each sample. A total of 357 genes with a minimum expression change of 4-fold (p-adj<0.05) were identified as responsive to UVB. The molecular genetic response of Xiphophorus skin to UVB exposure permitted assessment of; (1) the basal expression level of each transcript for each skin sample, (2) the changes in expression levels for each gene in the transcriptome upon exposure to increasing doses of UVB, and (3) clusters of genes that exhibit similar patterns of change in expression upon UVB exposure. These data provide a foundation for understanding the molecular genetic response of fish skin to UVB exposure.

Indexed as

AnimalsBase SequenceCyprinodontiformesGene ExpressionMaleMolecular Sequence DataSequence Analysis, RNASkinUltraviolet RaysFishesGene expressionRNA-SeqTranscriptomeUltraviolet lightUVBXiphophorus

Identifiers

PMID24556253
PMCPMC4067948
OpenAlexW1967465967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.