Evidence map›Paper›PMID 24556010›Full record

SynthesisThe Lancet. Neurology2014

Neurobehavioural effects of developmental toxicity.

Philippe Grandjean, Philip J Landrigan

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Lancet. Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 726 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
726citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

726 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Neurodevelopmental Outcomes Associated with Early-Life Exposure to Heavy Metals: A Systematic Review.International journal of environmental research and public health · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. A Systematic Review and Meta-analysis of Chemical Exposures and Attention-Deficit/Hyperactivity Disorder in Children.Prevention science : the official journal of the Society for Prevention Research · 2024
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Article
  11. Review of in vitro approaches for assessing the toxicity of chemical stressors across diverse physiological systems.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Microplastics and Nanoplastics in Food: Dietary Toxicology Beyond Particle Counts.Comprehensive reviews in food science and food safety · 2026
    Review
  18. Review
  19. Article
  20. Article

666 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Philippe GrandjeanDepartment of Environmental Medicine, University of Southern Denmark, Odense, Denmark; Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. Electronic address: pgrand@hsph.harvard.edu.
Philip J LandriganIcahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

PRENATAL PCB EXPOSURE &NEURODEVELOPMENTAL OUTCOMES IN ADOLESCENCE &ADULTHOODP01ES009584 · NIEHS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI WOLFF, MARY S · 1999 to 2009
$7.3M
MERCURY-ASSOCIATED NEUROBEHAVIORAL DEFICIT IN CHILDRENU01ES009797 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GRANDJEAN, PHILIPPE ADAM · 2000 to 2004
$2.1M
Mercury-Associated Neurobehavioral Deficit in ChildrenR01ES009797 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI GRANDJEAN, PHILIPPE ADAM · 2007 to 2011
$2.0M
Effects of perinatal endocrine disrupters in childrenR01ES011681 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GRANDJEAN, PHILIPPE ADAM · 2001 to 2004
$1.3M
NIEHS NIH HHS ES09584NIEHS NIH HHS ES09797NIEHS NIH HHS ES11687NIEHS NIH HHS P01 ES009584NIEHS NIH HHS R01 ES009797NIEHS NIH HHS R01 ES011681NIEHS NIH HHS U01 ES009797
6 · The paper itself

Abstract

Neurodevelopmental disabilities, including autism, attention-deficit hyperactivity disorder, dyslexia, and other cognitive impairments, affect millions of children worldwide, and some diagnoses seem to be increasing in frequency. Industrial chemicals that injure the developing brain are among the known causes for this rise in prevalence. In 2006, we did a systematic review and identified five industrial chemicals as developmental neurotoxicants: lead, methylmercury, polychlorinated biphenyls, arsenic, and toluene. Since 2006, epidemiological studies have documented six additional developmental neurotoxicants-manganese, fluoride, chlorpyrifos, dichlorodiphenyltrichloroethane, tetrachloroethylene, and the polybrominated diphenyl ethers. We postulate that even more neurotoxicants remain undiscovered. To control the pandemic of developmental neurotoxicity, we propose a global prevention strategy. Untested chemicals should not be presumed to be safe to brain development, and chemicals in existing use and all new chemicals must therefore be tested for developmental neurotoxicity. To coordinate these efforts and to accelerate translation of science into prevention, we propose the urgent formation of a new international clearinghouse.

Indexed as

AnimalsBrainDevelopmental DisabilitiesEnvironmental ExposureHumansMethylmercury CompoundsNeurotoxicity SyndromesPolychlorinated Biphenylsdimethyl mercuryMethylmercury CompoundsPolychlorinated Biphenyls

Identifiers

PMID24556010
PMCPMC4418502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.