ReviewTrends in genetics : TIG2014
CRISPR-based technologies: prokaryotic defense weapons repurposed.
Review in Trends in genetics : TIG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 107 citations in OpenAlex.
- Recent applications, future perspectives, and limitations of the CRISPR-Cas system.Molecular therapy. Nucleic acids · 2025Review
- CRISPR and gene editing for kidney diseases: where are we?Clinical kidney journal · 2025Review
- CRISPR-Cas systems in enterococci.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Review
- Type III-A CRISPR systems as a versatile gene knockdown technology.RNA (New York, N.Y.) · 2022Article
- Engineering drought-tolerant apple by knocking down sixHorticulture research · 2022Article
- Can genetic engineering-based methods for gene function identification be eclipsed by genome editing in plants? A comparison of methodologies.Molecular genetics and genomics : MGG · 2021Review
- The Current Status of Gene Therapy for the Treatment of Cancer.Biologics : targets & therapy · 2021Review
- CRISPR-Cas9/CRISPRi tools for cell factory construction in E. coli.World journal of microbiology & biotechnology · 2020Review
- Investigation of direct repeats, spacers and proteins associated with clustered regularly interspaced short palindromic repeat (CRISPR) system of Vibrio parahaemolyticus.Molecular genetics and genomics : MGG · 2019Article
- CRISPR-Based Technologies: Impact of RNA-Targeting Systems.Molecular cell · 2018Review
- Real-time observation of flexible domain movements in CRISPR-Cas9.The EMBO journal · 2018Article
- Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies.Angewandte Chemie (International ed. in English) · 2018Review
- CRISPR/Cas9-Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development.Viruses · 2018Review
- The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9.ACS synthetic biology · 2017Article
- Not all predicted CRISPR-Cas systems are equal: isolated cas genes and classes of CRISPR like elements.BMC bioinformatics · 2017Article
- Programmable type III-A CRISPR-Cas DNA targeting modules.PloS one · 2017Article
- Gene Repression in Haloarchaea Using the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas I-B System.The Journal of biological chemistry · 2016Article
- Distinct patterns of Cas9 mismatch tolerance in vitro and in vivo.Nucleic acids research · 2016Article
- Friendly Fire: Biological Functions and Consequences of Chromosomal Targeting by CRISPR-Cas Systems.Journal of bacteriology · 2016Review
- Programmed Self-Assembly of an Active P22-Cas9 Nanocarrier System.Molecular pharmaceutics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To combat potentially deadly viral infections, prokaryotic microbes enlist small RNA-based adaptive immune systems (CRISPR-Cas systems) that protect through sequence-specific recognition and targeted destruction of viral nucleic acids (either DNA or RNA depending on the system). Here, we summarize rapid progress made in redirecting the nuclease activities of these microbial immune systems to bind and cleave DNA or RNA targets of choice, by reprogramming the small guide RNAs of the various CRISPR-Cas complexes. These studies have demonstrated the potential of Type II CRISPR-Cas systems both as efficient and versatile genome-editing tools and as potent and specific regulators of gene expression in a broad range of cell types (including human) and organisms. Progress is also being made in developing a Type III RNA-targeting CRISPR-Cas system as a novel gene knockdown platform to investigate gene function and modulate gene expression for metabolic engineering in microbes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.