ArticleBMC genomics2014
Genomic characteristics and comparative genomics analysis of Penicillium chrysogenum KF-25.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Hybrid Whole-Genome Sequencing ofInternational journal of molecular sciences · 2026Article
- Identification of targets for high penicillin G production in an industrial strain of Penicillium rubens.Applied microbiology and biotechnology · 2026Article
- Enhancing wheat bran deconstruction with enzyme cocktails from Penicillium spp. and Trichoderma harzianum: the impact of β-glucosidase supplementation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Comparative genome analysis of patulin-producingPeerJ · 2025Article
- Genomic characterization and identification of candidate genes for putative podophyllotoxin biosynthesis pathway in Penicillium herquei HGN12.1C.Microbial biotechnology · 2024Article
- Genomic insights into Penicillium chrysogenum adaptation to subseafloor sedimentary environments.BMC genomics · 2024Article
- Comparative analysis ofFrontiers in microbiology · 2022Article
- Omics Approaches Applied toGenes · 2020Review
- Insight into the Genome of DiverseInternational journal of molecular sciences · 2020Review
- Whole genome analysis of Aspergillus sojae SMF 134 supports its merits as a starter for soybean fermentation.Journal of microbiology (Seoul, Korea) · 2019Article
- Influence of R and S enantiomers of 1-octen-3-ol on gene expression of Penicillium chrysogenum.Journal of industrial microbiology & biotechnology · 2019Article
- Transcription Factor NsdD Regulates the Expression of Genes Involved in Plant Biomass-Degrading Enzymes, Conidiation, and Pigment Biosynthesis in Penicillium oxalicum.Applied and environmental microbiology · 2018Article
- Article
- Contrasting Genomic Diversity in Two Closely Related Postharvest Pathogens: Penicillium digitatum and Penicillium expansum.Genome biology and evolution · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPenicillium chrysogenum has been used in producing penicillin and derived β-lactam antibiotics for many years. Although the genome of the mutant strain P. chrysogenum Wisconsin 54-1255 has already been sequenced, the versatility and genetic diversity of this species still needs to be intensively studied. In this study, the genome of the wild-type P. chrysogenum strain KF-25, which has high activity against Ustilaginoidea virens, was sequenced and characterized.
resultsThe genome of KF-25 was about 29.9 Mb in size and contained 9,804 putative open reading frames (orfs). Thirteen genes were predicted to encode two-component system proteins, of which six were putatively involved in osmolarity adaption. There were 33 putative secondary metabolism pathways and numerous genes that were essential in metabolite biosynthesis. Several P. chrysogenum virus untranslated region sequences were found in the KF-25 genome, suggesting that there might be a relationship between the virus and P. chrysogenum in evolution. Comparative genome analysis showed that the genomes of KF-25 and Wisconsin 54-1255 were highly similar, except that KF-25 was 2.3 Mb smaller. Three hundred and fifty-five KF-25 specific genes were found and the biological functions of the proteins encoded by these genes were mainly unknown (232, representing 65%), except for some orfs encoding proteins with predicted functions in transport, metabolism, and signal transduction. Numerous KF-25-specific genes were found to be associated with the pathogenicity and virulence of the strains, which were identical to those of wild-type P. chrysogenum NRRL 1951.
conclusionGenome sequencing and comparative analysis are helpful in further understanding the biology, evolution, and environment adaption of P. chrysogenum, and provide a new tool for identifying further functional metabolites.
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