ArticleBMC cancer2014
Retrospective analysis of 104 histologically proven adult brainstem gliomas: clinical symptoms, therapeutic approaches and prognostic factors.
Article in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Delayed Imaging Response After Chemoradiotherapy in a Patient with Unresectable Brainstem Pilocytic Astrocytoma.Diagnostics (Basel, Switzerland) · 2026Article
- Intraoperative Neurophysiological Monitoring During Adult Brainstem Glioma Resection: Association Between Electrophysiological Changes and Early Neurological Outcome.Current oncology (Toronto, Ont.) · 2026Article
- Progressive Dysphagia Revealing Glioma: Diagnostic Overshadowing by Suspected Myasthenia Gravis.European journal of case reports in internal medicine · 2026Article
- Clinical Nomogram Model for Predicting the Prognosis of Patients with Brainstem Glioma : A Population-Based Study.Journal of Korean Neurosurgical Society · 2025Article
- Epidemiological characteristics and prognostic factors of high-grade brainstem glioma for all ages and the establishment of a nomogram.Translational cancer research · 2025Article
- Exploration of the prognostic value of the resection of adult brainstem high-grade glioma based on competing risk model, propensity score matching, and conditional survival rate.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Compassionate Treatment of Brainstem Tumors with Boron Neutron Capture Therapy: A Case Series.Life (Basel, Switzerland) · 2022Article
- Prognostic factors in adult brainstem glioma: a tertiary care center analysis and review of the literature.Journal of neurology · 2022Review
- Adult brainstem glioma: a multicentre retrospective analysis of 47 Italian patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center.Journal of clinical neurology (Seoul, Korea) · 2021Article
- The Survival Benefits of Surgical Resection and Adjuvant Therapy for Patients With Brainstem Glioma.Frontiers in oncology · 2021Article
- The Epidemiological Characteristics and Prognostic Factors of Low-Grade Brainstem Glioma: A Real-World Study of Pediatric and Adult Patients.Frontiers in oncology · 2020Article
- The role of radiation and chemotherapy in adult patients with high-grade brainstem gliomas: results from the National Cancer Database.Journal of neuro-oncology · 2020Article
- Analysis of the Factors Affecting the Prognosis of Glioma Patients.Open medicine (Warsaw, Poland) · 2019Article
- Treatment of adult brainstem glioma with combined antiangiogenic therapy: a case report and literature review.OncoTargets and therapy · 2019Article
- Identification of Grade-associated MicroRNAs in Brainstem Gliomas Based on Microarray Data.Journal of Cancer · 2018Article
- Article
- High-Grade Glioma of the Ventrolateral Medulla in an Adult: Case Presentation and Discussion of Surgical Considerations.Case reports in neurological medicine · 2016Article
- Article
- Adult brainstem gliomas: Correlation of clinical and molecular features.Journal of the neurological sciences · 2015Article
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Authors and funding
6 authors.
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Abstract
backgroundAdult brainstem gliomas are rare primary brain tumors (<2% of gliomas). The goal of this study was to analyze clinical, prognostic and therapeutic factors in a large series of histologically proven brainstem gliomas.
methodsBetween 1997 and 2007, 104 patients with a histologically proven brainstem glioma were retrospectively analyzed. Data about clinical course of disease, neuropathological findings and therapeutic approaches were analyzed.
resultsThe median age at diagnosis was 41 years (range 18-89 years), median KPS before any operative procedure was 80 (range 20-100) and median survival for the whole cohort was 18.8 months. Histopathological examinations revealed 16 grade I, 31 grade II, 42 grade III and 14 grade IV gliomas. Grading was not possible in 1 patient. Therapeutic concepts differed according to the histopathology of the disease. Median overall survival for grade II tumors was 26.4 months, for grade III tumors 12.9 months and for grade IV tumors 9.8 months. On multivariate analysis the relative risk to die increased with a KPS ≤ 70 by factor 6.7, with grade III/IV gliomas by the factor 1.8 and for age ≥ 40 by the factor 1.7. External beam radiation reduced the risk to die by factor 0.4.
conclusionAdult brainstem gliomas present with a wide variety of neurological symptoms and postoperative radiation remains the cornerstone of therapy with no proven benefit of adding chemotherapy. Low KPS, age ≥ 40 and higher tumor grade have a negative impact on overall survival.
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