ArticleCase reports in nephrology2012
AL-Amyloidosis Presenting with Negative Congo Red Staining in the Setting of High Clinical Suspicion: A Case Report.
Article in Case reports in nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- The Homoserine DehydrogenaseMicroorganisms · 2026Article
- Diagnostic value of bone marrow smear for amyloid detection and its correlation with clinical features in systemic light-chain amyloidosis.Scientific reports · 2026Article
- Review
- Biofilm Formation, Antibiotic Resistance, and Virulence Analysis of Human and Avian OriginVeterinary sciences · 2025Article
- Epidemiology and clinical presentation of kidney amyloidosis have changed over the past three decades: a nationwide population-based study.BMC nephrology · 2025Article
- Quantitative diagnosis of amyloid without Congo red staining using polarized light microscopy.Biomedical optics express · 2025Article
- Antibody Aggregation: A Problem Within the Biopharmaceutical Industry and Its Role in AL Amyloidosis Disease.The protein journal · 2025Review
- Venetoclax Plus CyBorD Induction Therapy and Venetoclax Maintenance Treatment for Immunoglobulin Light Chain Amyloidosis with t(11;14) Translocation.Current oncology (Toronto, Ont.) · 2025Article
- Amyloid consults do not have to be vexing.Hematology. American Society of Hematology. Education Program · 2023Article
- Unicentric Castleman's disease associated with malignant cardiac Amyloid-A amyloidosis: a case report.European heart journal. Case reports · 2023Article
- Secondary renal amyloidosis due to primary Sjogren's syndrome: a case report.Annals of medicine and surgery (2012) · 2023Article
- Evaluation of laboratory diagnostic tests for light-chain clonality and bone marrow findings in AL amyloidosis.Blood research · 2023Article
- Flexor tenosynovectomy in carpal tunnel syndrome as a screening tool for early diagnosis of amyloidosis.Irish journal of medical science · 2022Article
- Amyloidosis: What does pathology offer? The evolving field of tissue biopsy.Frontiers in cardiovascular medicine · 2022Review
- Negative Fat Pad Biopsy in Systemic AL: A Case Report Analyzing the Preferred Amyloidosis Screening Test.Diseases (Basel, Switzerland) · 2021Article
- Atypical Nodular Pulmonary Kappa Light-Chain Deposition.Case reports in pathology · 2021Article
- Renal amyloidosis: an update on diagnosis and pathogenesis.Protoplasma · 2020Review
- Amyloid light-chain amyloidosis with haemorrhagic bullous eruption disclosing multiple myeloma.International wound journal · 2020Article
- Intraocular amyloidosis with multifocal iris and anterior chamber translucent spherules.Indian journal of ophthalmology · 2019Article
- Congo Red and amyloids: history and relationship.Bioscience reports · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A histologic diagnosis of amyloidosis requires acquiring tissue containing amyloid fibrils from an affected organ or alternate site. The biopsy site and staining techniques may influence testing accuracy. We present a case in which systemic amyloidosis was suspected; however, biopsies of the bone marrow, an osteosclerotic bone lesion, arterial and venous vessels, and the fat pad were all negative for the diagnostic Congo red stain. An eventual renal biopsy demonstrated AL-amyloidosis, kappa light chain associated with extensive vascular interstitial, and glomerular, involvement. Choice of biopsy site, as well as staining and analysis of the tissue, can influence sensitivity and specificity of amyloid testing. Fat-pad biopsies are less invasive and offer reasonable sensitivity. Bone marrow samples are only diagnostic up to 63% of the time. A renal biopsy offers improved sensitivity and is generally safe in experienced hands, but is a more invasive procedure with increased number of relative contraindications and complications. The choice of the biopsy site should be based on considering the expected yield, accessibility of the site, and the risks associated with the procedure.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.