ArticleF1000Research2013
A computational analysis of the long-term regulation of arterial pressure.
Article in F1000Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- A stochastic, physiology-based digital twin model of hemostasis and oxygenation in trauma resuscitation.Research square · 2026Article
- A model to simulate human cardio-respiratory responses to different fluid resuscitation treatments after hemorrhagic injury.Frontiers in physiology · 2025Article
- Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment.Frontiers in pharmacology · 2024Article
- A multiscale finite element model of left ventricular mechanics incorporating baroreflex regulation.Computers in biology and medicine · 2024Article
- A homogenized constrained mixture model of cardiac growth and remodeling: analyzing mechanobiological stability and reversal.Biomechanics and modeling in mechanobiology · 2023Article
- A multiscale model of the cardiovascular system that regulates arterial pressure via closed loop baroreflex control of chronotropism, cell-level contractility, and vascular tone.Biomechanics and modeling in mechanobiology · 2022Article
- Computational models of cardiac hypertrophy.Progress in biophysics and molecular biology · 2021Review
- Seven Mathematical Models of Hemorrhagic Shock.Computational and mathematical methods in medicine · 2021Review
- Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats.JCI insight · 2020Article
- Cardiac and renal function interactions in heart failure with reduced ejection fraction: A mathematical modeling analysis.PLoS computational biology · 2020Article
- Deep phenotyping of cardiac function in heart transplant patients using cardiovascular system models.The Journal of physiology · 2020Article
- A Simple Cardiovascular Model for the Study of Hemorrhagic Shock.Computational and mathematical methods in medicine · 2020Article
- Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling.American journal of physiology. Heart and circulatory physiology · 2019Article
- Computational model-based assessment of baroreflex function from response to Valsalva maneuver.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Testing Computer Models Predicting Human Responses to a High-Salt Diet.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Clinical Applications of Patient-Specific Models: The Case for a Simple Approach.Journal of cardiovascular translational research · 2018Article
- Current Perspectives on Systemic Hypertension in Heart Failure with Preserved Ejection Fraction.Current hypertension reports · 2017Review
- Logical Issues With the Pressure Natriuresis Theory of Chronic Hypertension.American journal of hypertension · 2016Article
- An alternative hypothesis to the widely held view that renal excretion of sodium accounts for resistance to salt-induced hypertension.Kidney international · 2016Review
- Simulation of short-term pressure regulation during the tilt test in a coupled 3D-0D closed-loop model of the circulation.Biomechanics and modeling in mechanobiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The asserted dominant role of the kidneys in the chronic regulation of blood pressure and in the etiology of hypertension has been debated since the 1970s. At the center of the theory is the observation that the acute relationships between arterial pressure and urine production-the acute pressure-diuresis and pressure-natriuresis curves-physiologically adapt to perturbations in pressure and/or changes in the rate of salt and volume intake. These adaptations, modulated by various interacting neurohumoral mechanisms, result in chronic relationships between water and salt excretion and pressure that are much steeper than the acute relationships. While the view that renal function is the dominant controller of arterial pressure has been supported by computer models of the cardiovascular system known as the "Guyton-Coleman model", no unambiguous description of a computer model capturing chronic adaptation of acute renal function in blood pressure control has been presented. Here, such a model is developed with the goals of: 1. representing the relevant mechanisms in an identifiable mathematical model; 2. identifying model parameters using appropriate data; 3. validating model predictions in comparison to data; and 4. probing hypotheses regarding the long-term control of arterial pressure and the etiology of primary hypertension. The developed model reveals: long-term control of arterial blood pressure is primarily through the baroreflex arc and the renin-angiotensin system; and arterial stiffening provides a sufficient explanation for the etiology of primary hypertension associated with ageing. Furthermore, the model provides the first consistent explanation of the physiological response to chronic stimulation of the baroreflex.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.