ArticleAnnals of the rheumatic diseases1988
Differential response to compressive loads of zones of canine hyaline articular cartilage: micromechanical, light and electron microscopic studies.
Article in Annals of the rheumatic diseases, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Contrast-enhanced XROMM reveals in vivo soft tissue interactions in the hip of Alligator mississippiensis.Journal of anatomy · 2020Article
- Functional properties of chondrocytes and articular cartilage using optical imaging to scanning probe microscopy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation.Arthritis research & therapy · 2015Article
- Direct Visualisation of the Depth-Dependent Mechanical Properties of Full-Thickness Articular Cartilage.Open journal of orthopedics · 2012Article
- Molecular and morphological adaptations in compressed articular cartilage by polarized light microscopy and Fourier-transform infrared imaging.Journal of structural biology · 2008Article
- The surface contour of articular cartilage in an intact, loaded joint.Journal of anatomy · 1999Article
- Calcium phosphate crystal distribution in the superficial zone of human femoral head articular cartilage.Journal of anatomy · 1992Article
- Micromechanical testing of articular cartilage: recent improvements to test apparatus.Annals of the rheumatic diseases · 1988Article
- Video microscopy to quantitate the inhomogeneous equilibrium strain within articular cartilage during confined compression.Annals of biomedical engineeringArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thin (100 micron) perpendicular slices of canine femoral condylar cartilage were placed horizontally on the stage of a Nachet microscope and viewed by transmitted light in the differential interference contrast mode. Each slice was held on the microscope stage by a loading rig and tested mechanically in compression. Measured loads to a maximum of approximately 2-3 MN/m2 were applied to the end of the slice corresponding to the articular surface. Photographs were taken of the cartilage before and during loading, and the distance by which selected chondrocytes were displaced was used as an index of mechanical strain, i.e., of change in length/original length. Maximum strains were observed in the superficial cartilage zone. Minimum strains were recorded in the mid-zone, at a depth corresponding to approximately 75% of the total cartilage thickness. The relative concentrations of cartilage collagen (COL) and proteoglycan (PG) were assessed by the light and electron microscopic histochemical study of cartilage sections taken from contiguous blocks. Superficial cartilage, which deformed most, had high concentrations of oriented COL fibres, low concentrations of PG. Mid-zone cartilage, which deformed least, had lower concentrations of randomly arrayed COL fibres but relatively high concentrations of PG.
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