ArticleMolecular biology of the cell2014
Nucleolus-tethering system (NoTS) reveals that assembly of photobodies follows a self-organization model.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Twenty-five years of photobodies: formation, composition, and the 2-compartment logic of phytochrome B signaling.Plant physiology · 2026Review
- What is going on inside of phytochrome B photobodies?The Plant cell · 2024Review
- Distinguishing individual photobodies using Oligopaints reveals thermo-sensitive and -insensitive phytochrome B condensation at distinct subnuclear locations.Nature communications · 2024Article
- Nuclear dynamics: Formation of bodies and trafficking in plant nuclei.Frontiers in plant science · 2022Review
- Out of the Dark and Into the Light: A New View of Phytochrome Photobodies.Frontiers in plant science · 2021Review
- B-box transcription factor 28 regulates flowering by interacting with constans.Scientific reports · 2020Article
- Tidying-up the plant nuclear space: domains, functions, and dynamics.Journal of experimental botany · 2020Review
- Novel Fluorescence Arginine Analogue as a Sensor for Direct Identification and Imaging of Nitric Oxide Synthase-like Enzymes in Plants.Scientific reports · 2016Article
- The redundancy of the mammalian heterochromatic compartment.Current opinion in genetics & development · 2016Review
- Integration of Light and Photoperiodic Signaling in Transcriptional Nuclear Foci.Developmental cell · 2015Article
- Chromatin dynamics during cellular differentiation in the female reproductive lineage of flowering plants.The Plant journal : for cell and molecular biology · 2015Review
- Molecular mechanisms for mediating light-dependent nucleo/cytoplasmic partitioning of phytochrome photoreceptors.The New phytologist · 2015Review
- Functional organization and dynamics of the cell nucleus.Frontiers in plant science · 2014Review
- Nucleolar tethering mediates pairing between the IgH and Myc loci.Nucleus (Austin, Tex.)Article
- Nucleolus-tethering system (NoTS).Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein-protein interactions play essential roles in regulating many biological processes. At the cellular level, many proteins form nuclear foci known as nuclear bodies in which many components interact with each other. Photobodies are nuclear bodies containing proteins for light-signaling pathways in plants. What initiates the formation of photobodies is poorly understood. Here we develop a nucleolar marker protein nucleolin2 (Nuc2)-based method called the nucleolus-tethering system (NoTS) by artificially tethering a protein of interest to the nucleolus to analyze the initiation of photobodies. A candidate initiator is evaluated by visualizing whether a protein fused with Nuc2 forms body-like structures at the periphery of the nucleolus, and other components are recruited to the de novo-formed bodies. The interaction between two proteins can also be revealed through relocation and recruitment of interacting proteins to the nucleolus. Using the NoTS, we test the interactions among components in photobodies. In addition, we demonstrate that components of photobodies such as CONSTITUTIVELY PHOTOMORPHOGENIC 1, photoreceptors, and transcription factors tethered to the nucleolus have the capacity to form body-like structures at the periphery of the nucleolus, which contain other components of photobodies, suggesting a self-organization model for the biogenesis of photobodies.
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