ArticleMolecular biology of the cell2014
hemingway is required for sperm flagella assembly and ciliary motility in Drosophila.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Proteomic and structural comparison between cilia from primary ciliary dyskinesia patients with a DNAH5 defect.Frontiers in molecular biosciences · 2025Article
- A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation.Science advances · 2023Article
- A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans.The EMBO journal · 2023Article
- Historic samples reveal loss of wild genotype through domestic chicken introgression during the Anthropocene.PLoS genetics · 2023Article
- Mutation inFrontiers in cell and developmental biology · 2022Article
- Structural and functional characterization of a putative de novo gene in Drosophila.Nature communications · 2021Article
- Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility.PLoS genetics · 2020Article
- Dynein assembly factor with WD repeat domains 1 (DAW1) is required for the function of motile cilia in the planarian Schmidtea mediterranea.Development, growth & differentiation · 2020Article
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- System analysis of teratozoospermia mRNA profile based on integrated bioinformatics tools.Molecular medicine reports · 2018Article
- Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes.G3 (Bethesda, Md.) · 2018Article
- Article
- Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing.Scientific reports · 2015Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cilia play major functions in physiology and development, and ciliary dysfunctions are responsible for several diseases in humans called ciliopathies. Cilia motility is required for cell and fluid propulsion in organisms. In humans, cilia motility deficiencies lead to primary ciliary dyskinesia, with upper-airways recurrent infections, left-right asymmetry perturbations, and fertility defects. In Drosophila, we identified hemingway (hmw) as a novel component required for motile cilia function. hmw encodes a 604-amino acid protein characterized by a highly conserved coiled-coil domain also found in the human orthologue, KIAA1430. We show that HMW is conserved in species with motile cilia and that, in Drosophila, hmw is expressed in ciliated sensory neurons and spermatozoa. We created hmw-knockout flies and found that they are hearing impaired and male sterile. hmw is implicated in the motility of ciliated auditory sensory neurons and, in the testis, is required for elongation and maintenance of sperm flagella. Because HMW is absent from mature flagella, we propose that HMW is not a structural component of the motile axoneme but is required for proper acquisition of motile properties. This identifies HMW as a novel, evolutionarily conserved component necessary for motile cilium function and flagella assembly.
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