ArticleCerebral cortex (New York, N.Y. : 1991)2015
The Genetic Association Between Neocortical Volume and General Cognitive Ability Is Driven by Global Surface Area Rather Than Thickness.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.Nature communications · 2020Pooled it
- The genetic architecture of the human cerebral cortex.Science (New York, N.Y.) · 2020Pooled it
- Quantification of planar cortical magnification with optimal transport and topological smoothing.NeuroImage · 2026Article
- Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance.Translational psychiatry · 2026Article
- Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population.Genetics and molecular biology · 2026Article
- Associations of Wearable-Measured Sleep and Physical Activity With Memory Performance in Older Adults: Cross-Sectional Study With Actigraphy and MRI.JMIR aging · 2025Observational
- Cerebral cortical structures linked to intelligence.bioRxiv : the preprint server for biology · 2025Article
- A lifespan perspective on cognitive reserve and risk for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- rsfMRI-based brain entropy is negatively correlated with gray matter volume and surface area.Brain structure & function · 2025Article
- Cortical Surface Area Profile Mediates Effects of Childhood Disadvantage on Later-Life General Cognitive Ability.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Linking cortical surface area to computational properties in human visual perception.iScience · 2024Article
- Long-term impact of digital media on brain development in children.Scientific reports · 2024Article
- Morphometric network-based abnormalities correlate with psychiatric comorbidities and gene expression in PCDH19-related developmental and epileptic encephalopathy.Translational psychiatry · 2024Article
- Higher cortical thickness/volume in Alzheimer's-related regions: protective factor or risk factor?Neurobiology of aging · 2023Article
- CDKL5 deficiency disorder: progressive brain atrophy may be part of the syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Morphometry and network-based atrophy patterns in SCN1A-related Dravet syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Co-twin design in brain imaging-review on biomarkers of Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2023Review
- Brain structure, phenotypic and genetic correlates of reading performance.Nature human behaviour · 2023Article
- Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study.Frontiers in neuroscience · 2023Article
- Deviations from normative brain white and gray matter structure are associated with psychopathology in youth.Developmental cognitive neuroscience · 2022Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Total gray matter volume is associated with general cognitive ability (GCA), an association mediated by genetic factors. It is expectable that total neocortical volume should be similarly associated with GCA. Neocortical volume is the product of thickness and surface area, but global thickness and surface area are unrelated phenotypically and genetically in humans. The nature of the genetic association between GCA and either of these 2 cortical dimensions has not been examined. Humans possess greater cognitive capacity than other species, and surface area increases appear to be the primary driver of the increased size of the human cortex. Thus, we expected neocortical surface area to be more strongly associated with cognition than thickness. Using multivariate genetic analysis in 515 middle-aged twins, we demonstrated that both the phenotypic and genetic associations between neocortical volume and GCA are driven primarily by surface area rather than thickness. Results were generally similar for each of 4 specific cognitive abilities that comprised the GCA measure. Our results suggest that emphasis on neocortical surface area, rather than thickness, could be more fruitful for elucidating neocortical-GCA associations and identifying specific genes underlying those associations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.