ArticleCerebral cortex (New York, N.Y. : 1991)2015
Transient Hearing Loss Within a Critical Period Causes Persistent Changes to Cellular Properties in Adult Auditory Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58 citing papers in PubMed, 93 citations in OpenAlex.
- Characterizing behavioral effects of early-life stress in an animal model of auditory processing.Physiology & behavior · 2026Article
- Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Developmental and early-life stress-induced effects on 5-HTNeurobiology of stress · 2026Article
- Developmental and Early-Life Stress-Induced Effects on 5-HTbioRxiv : the preprint server for biology · 2025Article
- A sensitive period for the development of episodic-like memory in mice.Current biology : CB · 2025Article
- The cingulate cortex facilitates auditory perception under challenging listening conditions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Formation of an auditory sensory representation in posterior striatum emerges during a brief temporal window of associative learning in normal and hearing-impaired gerbils.Frontiers in systems neuroscience · 2025Article
- Developmental hearing loss-induced perceptual deficits are rescued by genetic restoration of cortical inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Experience-Dependent Plasticity in Nucleus Laminaris of the Barn Owl.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Does age protect against loss of tonotopy after acute deafness in adulthood?Frontiers in cellular neuroscience · 2024Article
- Language Exposure for Preterm Infants is Reduced Relative to Fetuses.The Journal of pediatrics · 2023Article
- An Animal Model of Neonatal Intensive Care Unit Exposure to Light and Sound in the Preterm Infant.Integrative and comparative biology · 2023Article
- Increased Central Auditory Gain and Decreased Parvalbumin-Positive Cortical Interneuron Density in theBiological psychiatry global open science · 2023Article
- Preservation of developmental spontaneous activity enables early auditory system maturation in deaf mice.PLoS biology · 2023Article
- Early-Life Stress Impairs Perception and Neural Encoding of Rapid Signals in the Auditory Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Crossmodal plasticity in hearing loss.Trends in neurosciences · 2023Review
- Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABAbioRxiv : the preprint server for biology · 2023Article
- Early-life stress affects Mongolian gerbil interactions with conspecific vocalizations in a sex-specific manner.Frontiers in behavioral neuroscience · 2023Article
- Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked CNTNAP2 gene.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Auditory processing remains sensitive to environmental experience during adolescence in a rodent model.Nature communications · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sensory deprivation can induce profound changes to central processing during developmental critical periods (CPs), and the recovery of normal function is maximal if the sensory input is restored during these epochs. Therefore, we asked whether mild and transient hearing loss (HL) during discrete CPs could induce changes to cortical cellular physiology. Electrical and inhibitory synaptic properties were obtained from auditory cortex pyramidal neurons using whole-cell recordings after bilateral earplug insertion or following earplug removal. Varying the age of HL onset revealed brief CPs of vulnerability for membrane and firing properties, as well as, inhibitory synaptic currents. These CPs closed 1 week after ear canal opening on postnatal day (P) 18. To examine whether the cellular properties could recover from HL, earplugs were removed prior to (P17) or after (P23), the closure of these CPs. The earlier age of hearing restoration led to greater recovery of cellular function, but firing rate remained disrupted. When earplugs were removed after the closure of these CPs, several changes persisted into adulthood. Therefore, long-lasting cellular deficits that emerge from transient deprivation during a CP may contribute to delayed acquisition of auditory skills in children who experience temporary HL.
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