Evidence map›Paper›PMID 24554654›Full record

ArticleJournal of virology2014

Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.

Pinghuang Liu, Latonya D Williams, Xiaoying Shen, Mattia Bonsignori, Nathan A Vandergrift, R Glenn Overman, M Anthony Moody, Hua-Xin Liao, Daniel J Stieh, Kerrie L McCotter and 5 more

Abstract read
In one paragraph

Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Trial
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  14. Article
  15. HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies.AIDS research and human retroviruses · 2017
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pinghuang LiuDuke Human Vaccine Institute, Duke University, Durham, North Carolina, USA.
Latonya D Williams
Xiaoying Shen
Mattia Bonsignori
Nathan A Vandergrift
R Glenn Overman
M Anthony Moody
Hua-Xin Liao
Daniel J Stieh
Kerrie L McCotter
Audrey L French
Thomas J Hope
Robin Shattock
Barton F Haynes
Georgia D Tomaras

Funding

Viral Sequencing CoreU19AI067854 · NIAID · DUKE UNIVERSITY · PI BHARDWAJ, NINA · 2006 to 2011
$290.5M
Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI MCMICHAEL, ANDREW JAMES · 2012 to 2018
$204.7M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
CENTRAL LABORATORY FOR THE HIV VACCINES TRIALS NETWORKU01AI046725 · NIAID · DUKE UNIVERSITY · PI WEINHOLD, KENT J. · 2000 to 2005
$45.4M
Viral and Host Determinants of HIV-1 TransmissionU01AI067854 · NIAID · DUKE UNIVERSITY · PI HARRISON, STEPHEN COPLAN · 2005 to 2005
$14.9M
Tissue Culture and Virology Laboratory CoreP01AI082971 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI LANDAY, ALAN L · 2009 to 2013
$11.2M
Ruth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8M
NIAID NIH HHS 5U01 AI46725-05NIAID NIH HHS AI100645NIAID NIH HHS P01 AI082971NIAID NIH HHS P01AI082971NIAID NIH HHS P30 AI064518NIAID NIH HHS P30 AI64518NIAID NIH HHS T32 AI007392NIAID NIH HHS U01 AI046725NIAID NIH HHS U01 AI067854NIAID NIH HHS U01AI067854NIAID NIH HHS U19 AI067854NIAID NIH HHS UM1 AI100645
6 · The paper itself

Abstract

Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.

Indexed as

Antibody SpecificityAnimalsAntibodies, MonoclonalAntibodies, Neutralizingenv Gene Products, Human Immunodeficiency VirusFemaleHIV-1HIV AntibodiesImmunoglobulin GAntibodies, MonoclonalAntibodies, Neutralizingenv Gene Products, Human Immunodeficiency VirusHIV AntibodiesImmunoglobulin G

Identifiers

PMID24554654
PMCPMC3993833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.