ArticleEndocrine2014
Is lower uric acid level better? A combined cross-sectional and longitudinal study in the elderly.
Article in Endocrine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Dose-response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-alcoholic Fatty Liver Disease Incidence: A Meta-analysis of Prospective Studies.Scientific reports · 2015Pooled it
- Association between mortality and serum uric acid levels in non-diabetes-related chronic kidney disease: An analysis of the National Health and Nutrition Examination Survey, USA, 1999-2010.Scientific reports · 2020Article
- Clopidogrel resistance response in patients with coronary artery disease and metabolic syndrome: the role of hyperglycemia and obesity.Journal of geriatric cardiology : JGC · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between metabolic syndrome (MetS) and uric acid (UA) has been explored in many studies, but there is paucity of information on hypo-uricemia and MetS. The current study aimed to elucidate the relationship between the lower end of UA and MetS in elderly. Subjects aged ≥ 60 years who underwent routine health checkups were enrolled, and 10,579 were eligible for analysis. A cross-sectional study was first performed to determine the correlation between MetS and UA. The subjects were divided into two groups according to the lowest male MetS prevalence in each UA level (UA ≤ 5 and >5 mg/dl). A longitudinal study then excluded subjects with MetS at baseline to validate the UA level of those with the lowest incidence of MetS. In the prevalence of MetS in different UA levels, there was a J-shaped curve in males but a linear relationship in females. In males, waist circumference, systolic blood pressure, high-density lipoprotein, and triglyceride were correlated with UA in univariate analysis, but high-density lipoprotein became insignificant in multivariate analysis in UA >5 mg/dl (UA-high). Only fasting plasma glucose (FPG) was significantly related to UA ≤ 5 mg/dl (UA-low). The UA level of 4.5-5 mg/dl had the lowest risk of having MetS in odds ratio, log-rank test, and hazard ratio. A J-shaped phenomenon exists between UA and MetS in elderly men but not in elderly women and FPG seem to be the key factor in this. Lower UA does not provide benefits in elderly men. The new UA control strategy for the elderly warrants further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.