ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2014
Influence of maturity on nucleus-endplate integration in the ovine lumbar spine.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 29 citations in OpenAlex.
- Numerical Prediction of the Mechanical Failure of the Intervertebral Disc under Complex Loading Conditions.Materials (Basel, Switzerland) · 2017Article
- Staying connected: structural integration at the intervertebral disc-vertebra interface of human lumbar spines.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Molecular mechanisms of biological aging in intervertebral discs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Review
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeRecent investigations using an ovine spine model have established that the disc nucleus contains a highly convoluted fibre network with endplate-to-endplate connectivity, this connectivity being achieved via distinctive nodal attachment points. The purpose of this study was to investigate how this nodal anchoring system might be influenced by maturation.
methodsLumbar motion segments were dissected from newborn, 3, 12 months and fully mature ovine animals, subjected to a novel annular ring-severing procedure to remove the strain-limiting influence of the annulus, then either mechanically tested to destruction or examined microstructurally and ultrastructurally. The morphology of the nodes and their linear density within the relatively thin section planes were analysed to provide a basis for comparison between the four age groups.
resultsMechanical testing following ring severing revealed that the remaining nuclear material in all samples, irrespective of maturity, had the ability to transmit a substantial load from endplate to endplate. Imaging of the ring-severed samples from all age groups in their stretched, but unruptured state revealed the presence of axially aligned fibrosity in the nucleus region consistent with endplate-to-endplate connectivity. Endplate insertion nodes were observed in all age groups. Ultrastructural examination revealed that the fibrillar architecture of these nodes in the newborn discs was similar to that observed in the nodes of mature discs. However, there was a rapid increase in their linear density between birth and 3 months, after which this remained constant.
conclusionsThe nodal attachment points identified previously in mature ovine discs are also present in newborn, and 3- and 12-month-old animals with an initial rapid increase in their linear density between birth and 3 months, after which it remained constant. The size and morphology of the attachment points were similar for all ages. Our study suggests that the increase in nodal density in the ovine disc endplate is part of an adaptive response to the loading environment that the disc is exposed to from birth to maturity.
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