ArticleParasitology research2014
Increased concentration of serum TNF alpha and its correlations with arterial blood pressure and indices of renal damage in dogs infected with Babesia canis.
Article in Parasitology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Molecular prevalence and clinical profiles of canine babesiosis in northern India.BMC veterinary research · 2026Article
- Metabolomics Insights into Salivary Profile in Dogs withBiomolecules · 2025Article
- Selected cytokine and chemokine concentrations in equine autologous conditioned serum are similar under defined and practically relevant storage conditions.Frontiers in veterinary science · 2025Article
- The Diverse Pathogenicity of VariousPathogens (Basel, Switzerland) · 2023Review
- Haematological indices and immune response profiles in dogs naturally infected and co-infected with Dirofilaria repens and Babesia canis.Scientific reports · 2023Article
- Pathogenesis of Anemia in Canine Babesiosis: Possible Contribution of Pro-Inflammatory Cytokines and Chemokines-A Review.Pathogens (Basel, Switzerland) · 2023Review
- Phosphorylation regulation of cardiac proteins in Babesia microti infected mice in an effort to restore heart function.Parasites & vectors · 2022Article
- Disorders in Blood Circulation As a Probable Cause of Death in Dogs Infected withJournal of veterinary research · 2021Article
- Prevalence, genetic, and biochemical evaluation of immune response of police dogs infected withVeterinary world · 2021Article
- Combined Untargeted and Targeted Metabolomics Approaches Reveal Urinary Changes of Amino Acids and Energy Metabolism in Canine Babesiosis With Different Levels of Kidney Function.Frontiers in microbiology · 2021Article
- Evaluation of inflammatory biomarkers in goats naturally infected with Babesia ovis.Parasitology research · 2020Article
- Canine babesiosis - a disease rarely considered in the context of male infertility.Irish veterinary journal · 2020Article
- Prevalence of canine babesiosis and their risk factors among asymptomatic dogs in the federal capital territory, Abuja, Nigeria.Parasite epidemiology and control · 2020Article
- Urinary proteome of dogs with kidney injury during babesiosis.BMC veterinary research · 2019Article
- Hyponatraemia and Syndrome of Inappropriate Antidiuretic Hormone Secretion in Non-azotaemic Dogs with Babesiosis Associated with Decreased Arterial Blood Pressure.Journal of veterinary research · 2019Article
- MCP-1, KC-like and IL-8 as critical mediators of pathogenesis caused by Babesia canis.PloS one · 2018Article
- Article
- Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis.BMC veterinary research · 2017Article
- The prevalence of Dirofilaria repens in cats, healthy dogs and dogs with concurrent babesiosis in an expansion zone in central Europe.BMC veterinary research · 2016Article
- Protective effect of Xuebijing injection against acute lung injury induced by left ventricular ischemia/reperfusion in rabbits.Experimental and therapeutic medicine · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine babesiosis is a tick-borne disease caused by parasites of the genus Babesia. Tumour necrosis factor alpha (TNF-α) is a cytokine that plays a role in the pathogenesis of canine babesiosis. In this study, the authors determined the concentration of serum TNF-α in 11 dogs infected with Babesia canis and calculated Spearman's rank correlations between the concentration of TNF-α and blood pressure, and between TNF-α and indices of renal damage such as: fractional excretion of sodium (FE(Na(+))), urinary creatinine to serum creatinine ratio (UCr/SCr), renal failure index (RFI), urine specific gravity (USG) and urinary protein to urinary creatinine ratio (UPC). The results demonstrated statistically significant strong negative correlations between TNF-α and systolic arterial pressure (r = -0.7246), diastolic arterial pressure (r = -0.6642) and mean arterial pressure (r = -0.7151). Serum TNF-α concentration was also statistically significantly correlated with FE(Na(+)) (r = 0.7056), UCr/SCr (r = -0.8199), USG (r = -0.8075) and duration of the disease (r = 0.6767). The results of this study show there is an increase of serum TNF-α concentration during canine babesiosis, and the increased TNF-α concentration has an influence on the development of hypotension and renal failure in canine babesiosis. This probably results from the fact that TNF-α is involved in the production of nitric oxide and induction of vasodilation and hypotension, which may cause renal ischaemia and hypoxia, and finally acute tubular necrosis and renal failure.
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