ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Extracellular calcium controls the expression of two different forms of ripple-like hippocampal oscillations.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Modeling sources of interlaboratory variability in electrophysiological properties of mammalian neurons.Journal of neurophysiology · 2018Pooled it
- Supraphysiological Doses of Vitamin A Promote Changes in Hippocampal Oscillation Bands and Cardiac Activity in Wistar Rats.ACS omega · 2026Article
- High calcium concentrations reduce cellular excitability of mouse MNTB neurons.Brain research · 2023Article
- Alterations of sleep oscillations in Alzheimer's disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus.Brain research bulletin · 2022Review
- Sharp Wave Ripples in Alzheimer's Disease: In Search of Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Calcium and Spike Timing-Dependent Plasticity.Frontiers in cellular neuroscience · 2021Review
- Synaptic plasticity rules with physiological calcium levels.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Unit firing and oscillations at seizure onset in epileptic rodents.Neurobiology of disease · 2019Review
- Feedback and Feedforward Inhibition May Resonate Distinctly in the Ripple Symphony.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders.Epilepsia · 2017Review
- Single CA3 pyramidal cells trigger sharp waves in vitro by exciting interneurones.The Journal of physiology · 2016Article
- Article
- Evolution of temporal and spectral dynamics of pathologic high-frequency oscillations (pHFOs) during epileptogenesis.Epilepsia · 2015Article
- Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.The Journal of biological chemistry · 2015Article
- Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning.Hippocampus · 2015Review
- Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples.Nature neuroscience · 2015Article
- Conundrums of high-frequency oscillations (80-800 Hz) in the epileptic brain.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2015Review
- High-frequency voltage oscillations in cultured astrocytes.Physiological reports · 2015Article
- Interneuron activity leads to initiation of low-voltage fast-onset seizures.Annals of neurology · 2015Article
- Different mechanisms of ripple-like oscillations in the human epileptic subiculum.Annals of neurology · 2015Article
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4 authors.
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Abstract
Hippocampal high-frequency oscillations (HFOs) are prominent in physiological and pathological conditions. During physiological ripples (100-200 Hz), few pyramidal cells fire together coordinated by rhythmic inhibitory potentials. In the epileptic hippocampus, fast ripples (>200 Hz) reflect population spikes (PSs) from clusters of bursting cells, but HFOs in the ripple and the fast ripple range are vastly intermixed. What is the meaning of this frequency range? What determines the expression of different HFOs? Here, we used different concentrations of Ca(2+) in a physiological range (1-3 mM) to record local field potentials and single cells in hippocampal slices from normal rats. Surprisingly, we found that this sole manipulation results in the emergence of two forms of HFOs reminiscent of ripples and fast ripples recorded in vivo from normal and epileptic rats, respectively. We scrutinized the cellular correlates and mechanisms underlying the emergence of these two forms of HFOs by combining multisite, single-cell and paired-cell recordings in slices prepared from a rat reporter line that facilitates identification of GABAergic cells. We found a major effect of extracellular Ca(2+) in modulating intrinsic excitability and disynaptic inhibition, two critical factors shaping network dynamics. Moreover, locally modulating the extracellular Ca(2+) concentration in an in vivo environment had a similar effect on disynaptic inhibition, pyramidal cell excitability, and ripple dynamics. Therefore, the HFO frequency band reflects a range of firing dynamics of hippocampal networks.
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