ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Premotor spinal network with balanced excitation and inhibition during motor patterns has high resilience to structural division.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Theory and evidence of amplitude control by frequency detuning in a coupled neuronal oscillator system.PLoS computational biology · 2026Article
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
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- Decreased spinal inhibition leads to undiversified locomotor patterns.Biological cybernetics · 2025Article
- Intrathecal delivery of BDNF to the lumbar spinal cord modulates lumbar interneurons activity in a feline model of spinal cord injury.Journal of neural engineering · 2025Article
- Article
- Inhibitory conductance controls place field dynamics in the hippocampus.Cell reports · 2022Article
- Single-cell and ensemble activity of lumbar intermediate and ventral horn interneurons in the spinal air-stepping cat.Journal of neurophysiology · 2022Article
- GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks.Molecular neurobiology · 2021Review
- Why Firing Rate Distributions Are Important for Understanding Spinal Central Pattern Generators.Frontiers in human neuroscience · 2021Article
- Spatially extended balanced networks without translationally invariant connectivity.Journal of mathematical neuroscience · 2020Article
- Neurotransmitters and Motoneuron Contacts of Multifunctional and Behaviorally Specialized Turtle Spinal Cord Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Biological data questions the support of the self inhibition required for pattern generation in the half center model.PloS one · 2020Article
- Article
- Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord.Nature communications · 2019Article
- The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.Annual review of neuroscience · 2018Review
- Central pattern generators in the turtle spinal cord: selection among the forms of motor behaviors.Journal of neurophysiology · 2018Review
- Commentary: Synaptic Excitation in Spinal Motoneurons Alternates with Synaptic Inhibition and Is Balanced by Outward Rectification during Rhythmic Motor Network Activity.Frontiers in neural circuits · 2018Article
- Synaptic Excitation in Spinal Motoneurons Alternates with Synaptic Inhibition and Is Balanced by Outward Rectification during Rhythmic Motor Network Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Spinal Cord Preparation from Adult Red-eared Turtles for Electrophysiological Recordings during Motor Activity.Bio-protocol · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct measurements of synaptic inhibition (I) and excitation (E) to spinal motoneurons can provide an important insight into the organization of premotor networks. Such measurements of flexor motoneurons participating in motor patterns in turtles have recently demonstrated strong concurrent E and I as well as stochastic membrane potentials and irregular spiking in the adult turtle spinal cord. These findings represent a departure from the widespread acceptance of feedforward reciprocal rate models for spinal motor function. The apparent discrepancy has been reviewed as an experimental artifact caused by the distortion of local networks in the transected turtle spinal cord. We tested this assumption in the current study by performing experiments to assess the integrity of motor functions in the intact spinal cord and the cord transected at segments D9/D10. Excitatory and inhibitory synaptic inputs to motoneurons were estimated during rhythmic motor activity and demonstrated primarily intense inputs that consisted of qualitatively similar mixed E/I before and after the transection. To understand this high functional resilience, we used mathematical modeling of networks with recurrent connectivity that could potentially explain the balanced E/I. Both experimental and modeling data support the concept of a locally balanced premotor network consisting of recurrent E/I connectivity, in addition to the well known reciprocal network activity. The multifaceted synaptic connections provide spinal networks with a remarkable ability to remain functional after structural divisions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.