Evidence map›Paper›PMID 24553677›Full record

ArticleRheumatology international2014

Toll-like receptor-4 signaling: a new potential therapeutic pathway for rheumatoid arthritis.

Xiaofeng Li, Tao Xu, Yarui Wang, Cheng Huang, Jun Li

Abstract readComment
PubMed Publisher
In one paragraph

Article in Rheumatology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Direct tissue-sensing reprograms TLR4Communications biology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiaofeng LiSchool of Pharmacy, Anhui Medical University, Mei Shan Road, Hefei, 230032, Anhui Province, China.
Tao Xu
Yarui Wang
Cheng Huang
Jun Li
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Toll-like receptor-4 signaling (TLR-4) has been found to be over-expressed in rheumatoid arthritis (RA) synovium. Furthermore, it regulates the expression of pro-inflammatory cytokines. Based on the current evidences, TLR-4 may be a new potential therapeutic pathway for RA.

Indexed as

Asian PeoplePolymorphism, Single NucleotideArthritis, RheumatoidFemaleHumansMaleToll-Like Receptor 4Toll-Like Receptor 4

Identifiers

PMID24553677
OpenAlexW1987617704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.