Evidence map›Paper›PMID 24553612›Full record

ArticleRevista do Instituto de Medicina Tropical de Sao Paulo

Polyclonal outbreak of bloodstream infections caused by Burkholderia cepacia complex in hematology and bone marrow transplant outpatient units.

Icaro Boszczowski, Gladys Villas Boas do Prado, Mirian F Dalben, Roberto C P Telles, Maristela Pinheiro Freire, Thaís Guimarães, Maura S Oliveira, Juliana F Rosa, Robson E Soares, Pedro Enrique Dorlhiac Llacer and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista do Instituto de Medicina Tropical de Sao Paulo. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. A Nosocomial Outbreak ofAntibiotics (Basel, Switzerland) · 2025
    Article
  2. Review
  3. Genomics Reveals a Unique Clone ofFrontiers in microbiology · 2017
    Article
  4. Polyclonal outbreak of bacteremia caused by Burkholderia cepacia complex and the presumptive role of ultrasound gel.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Icaro BoszczowskiInfection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil, Infection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil.
Gladys Villas Boas do PradoInfection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil, Infection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil.
Mirian F DalbenInfection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil, Infection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil.
Roberto C P TellesDepartment of Infectious Diseases and LIM-54, University of São Paulo, São PauloSP, Brazil, Department of Infectious Diseases and LIM-54, University of São Paulo, São Paulo, SP, Brazil.
Maristela Pinheiro FreireInfection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil, Infection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil.
Thaís GuimarãesInfection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil, Infection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil.
Maura S OliveiraInfection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil, Infection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil.
Juliana F RosaDepartment of Infectious Diseases and LIM-54, University of São Paulo, São PauloSP, Brazil, Department of Infectious Diseases and LIM-54, University of São Paulo, São Paulo, SP, Brazil.
Robson E SoaresDepartment of Infectious Diseases and LIM-54, University of São Paulo, São PauloSP, Brazil, Department of Infectious Diseases and LIM-54, University of São Paulo, São Paulo, SP, Brazil.
Pedro Enrique Dorlhiac LlacerHematology Unit, Hospital das Clínicas, University of São Paulo, São PauloSP, Brazil, Hematology Unit, Hospital das Clínicas, University of São Paulo, São Paulo, SP, Brazil.
Frederico Luiz DulleyChief of Bone Marrow Transplant Unit, Hospital das Clínicas, University of São Paulo, São PauloSP, Brazil, Chief of Bone Marrow Transplant Unit, Hospital das Clínicas, University of São Paulo, São Paulo, SP, Brazil.
Silvia F CostaDepartment of Infectious Diseases and LIM-54, University of São Paulo, São PauloSP, Brazil, Department of Infectious Diseases and LIM-54, University of São Paulo, São Paulo, SP, Brazil.
Anna S LevinInfection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil, Infection Control Department, Hospital das Clinicas, Universidade de São Paulo, SP, Brazil.
Universidade de São Paulo · BRPontifícia Universidade Católica de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe objective was to describe an outbreak of bloodstream infections by Burkholderia cepacia complex (Bcc) in bone marrow transplant and hematology outpatients.

methodsOn February 15, 2008 a Bcc outbreak was suspected. 24 cases were identified. Demographic and clinical data were evaluated. Environment and healthcare workers' (HCW) hands were cultured. Species were determined and typed. Reinforcement of hand hygiene, central venous catheter (CVC) care, infusion therapy, and maintenance of laminar flow cabinet were undertaken. 16 different HCWs had cared for the CVCs. Multi-dose heparin and saline were prepared on counter common to both units.

findings14 patients had B. multivorans (one patient had also B. cenopacia), six non-multivorans Bcc and one did not belong to Bcc. Clone A B. multivorans occurred in 12 patients (from Hematology); in 10 their CVC had been used on February 11/12. Environmental and HCW cultures were negative. All patients were treated with meropenem, and ceftazidime lock-therapy. Eight patients (30%) were hospitalized. No deaths occurred. After control measures (multidose vial for single patient; CVC lock with ceftazidime; cleaning of laminar flow cabinet; hand hygiene improvement; use of cabinet to store prepared medication), no new cases occurred.

conclusionsThis polyclonal outbreak may be explained by a common source containing multiple species of Bcc, maybe the laminar flow cabinet common to both units. There may have been contamination by B. multivorans (clone A) of multi-dose vials.

Indexed as

Disease OutbreaksAdolescentAdultBacteremiaBone Marrow TransplantationBurkholderia cepacia complexBurkholderia InfectionsCatheter-Related InfectionsChildChild, PreschoolFemaleHematologic DiseasesHumansMaleMiddle AgedYoung Adult

Identifiers

PMID24553612
PMCPMC4085834
OpenAlexW2056373517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.