ArticlePsychopharmacology2014
Effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Social isolation at adolescence: a systematic review on behaviour related to cocaine, amphetamine and nicotine use in rats and mice.Psychopharmacology · 2021Pooled it
- A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens.Frontiers in neuroendocrinology · 2025Review
- Adolescent mice exhibit lower reward sensitivity than adults.Frontiers in behavioral neuroscience · 2025Article
- Friend of the Devil: Negative Social Influences Driving Substance Use Disorders.Frontiers in behavioral neuroscience · 2022Review
- HIV-Associated Apathy/Depression and Neurocognitive Impairments Reflect Persistent Dopamine Deficits.Cells · 2021Review
- Social isolation of adolescent male rats increases anxiety and KThe European journal of neuroscience · 2021Article
- A novel social fear conditioning procedure alters social behavior and mTOR signaling in differentially housed adolescent rats.Developmental psychobiology · 2021Article
- Long-Term Impacts of Post-weaning Social Isolation on Nucleus Accumbens Function.Frontiers in psychiatry · 2021Review
- The Effects of Drugs on Behavior Maintained by Social Contact: Role of Monoamines in Social Reinforcement.Frontiers in behavioral neuroscience · 2021Article
- Sex-dependent regulation of social reward by oxytocin receptors in the ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Monoacylglycerol lipase inhibition alters social behavior in male and female rats after post-weaning social isolation.Behavioural brain research · 2018Article
- A novel escapable social interaction test reveals that social behavior and mPFC activation during an escapable social encounter are altered by post-weaning social isolation and are dependent on the aggressiveness of the stimulus rat.Behavioural brain research · 2017Article
- A method for evaluating cocaine-induced social preference in rats.Journal of biological methods · 2017Article
- Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U.Biological psychiatry · 2016Article
- The neurobiology of social play and its rewarding value in rats.Neuroscience and biobehavioral reviews · 2016Review
- Preventative treatment in an animal model of ADHD: Behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- The Two Faces of Social Interaction Reward in Animal Models of Drug Dependence.Neurochemical research · 2016Review
- Brain regional differences in social encounter-induced Fos expression in male and female rats after post-weaning social isolation.Brain research · 2016Article
- Pro-social 50-kHz ultrasonic communication in rats: post-weaning but not post-adolescent social isolation leads to social impairments-phenotypic rescue by re-socialization.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationaleSocial interaction during drug exposure can potentiate cocaine reward. Isolation rearing (ISO) during adolescence increases social interaction and may amplify this potentiation.
objectivesThe objectives of this study are to determine whether ISO alters conditioned place preference (CPP) for cocaine when combined with a social cue and to determine whether ISO alters the effects of cocaine when combined with social cue on nucleus accumbens shell (NAcS) dopamine (DA) and serotonin (5-HT).
methodsMale and female rats were either ISO or group (GRP) reared for 4 weeks during adolescence. CPP was performed using a low dose of cocaine (2 mg/kg or saline) with or without exposure to a novel same-sex conspecific during conditioning. In vivo microdialysis was performed using the same parameters.
resultsISO rats engaged in more social and aggressive behaviors during conditioning relative to GRP. Cocaine reduced social and aggressive behaviors in all rats. CPP was not influenced by rearing condition. Cocaine produced significant CPP, and a social cue produced CPP only in males. In contrast, the interaction of cocaine and a social cue on NAcS DA and 5-HT differed depending upon rearing condition. In isolates, cocaine-induced DA was attenuated, while cocaine plus a social cue produced potentiated DA and 5-HT.
conclusionsExposure to a low dose of cocaine in the presence of a social cue produced additive effects on CPP while producing synergistic effects on DA and 5-HT in the NAcS of ISO rats. The aversive effects of this compound stimulus may negate the rewarding effects in isolates.
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