ReviewRevista Brasileira de terapia intensiva
Sepsis and pregnancy: do we know how to treat this situation?
Review in Revista Brasileira de terapia intensiva. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Towards a consensus definition of maternal sepsis: results of a systematic review and expert consultation.Reproductive health · 2017Pooled it
- Prognostic value of the obstetric specific scoring systems and four years' experience of a tertiary center.BMC pregnancy and childbirth · 2025Article
- Between guidelines and reality; the complex decision-making of acute cholecystitis in pregnancy.Langenbeck's archives of surgery · 2025Article
- Article
- Sepsis in obstetric care for the emergency clinician: A review.Seminars in perinatology · 2024Review
- Maternal septic shock due to Acinetobacter lwoffii infection:a case report.Fukushima journal of medical science · 2023Article
- Factors Associated with Increased Risk of Urosepsis during Pregnancy and Treatment Outcomes, in a Urology Clinic.Medicina (Kaunas, Lithuania) · 2023Article
- Association between antenatal corticosteroid treatment and severe adverse events in pregnant women.BMC medicine · 2023Article
- Review
- The continued evolution of peripartum anesthesiologists.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Article
- Physiological Changes and Interactions Between Microbiome and the Host During Pregnancy.Frontiers in cellular and infection microbiology · 2022Review
- Sepsis scoring systems and use of the Sepsis six care bundle in maternity hospitals.BMC pregnancy and childbirth · 2021Observational
- Refractory gram-negative septic shock complicated by extended purpura fulminans and multiple organ failure in a 23-year-old puerpera -a case report.Korean journal of anesthesiology · 2021Article
- Perinatal outcome in women with bacterial sepsis: A cross-sectional study from West China.Medicine · 2019Article
- Sepsis in Pregnancy: Recognition and Resuscitation.The western journal of emergency medicine · 2019Review
- Successful Term Pregnancy in a Second Trimester Female with Urosepsis: A Case Report.Journal of clinical and diagnostic research : JCDR · 2015Article
- High-flow nasal cannula in the treatment of acute hypoxemic respiratory failure in a pregnant patient: case report.Revista Brasileira de terapia intensivaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is defined as an acute inflammatory response syndrome secondary to an infectious focus. It has a high incidence, morbidity and mortality, causing substantial financial costs, especially due to complications such as septic shock and multiple organ dysfunction. The pathogen toxins associated with individual susceptibility culminate with cytokine release, which promotes a systemic inflammatory response that can progress to multiple organ dysfunction and eventual patient death. Specifically, sepsis incidence, morbidity and mortality are lower in pregnant women, as this group is typically younger with fewer comorbidities having a polymicrobial etiology resulting in sepsis. Pregnant women exhibit physiological characteristics that may confer specific clinical presentation and laboratory patterns during the sepsis course. Thus, a better understanding of these changes is critical for better identification and management of these patients. The presence of a fetus also requires unique approaches in a pregnant woman with sepsis. Sepsis treatment is based on certain guidelines that were established after major clinical trials, which, unfortunately, all classified pregnancy as a exclusion criteria. Thus, the treatment of sepsis in the general population has been extrapolated to the pregnant population, with the following main goals: maintenance of tissue perfusion with fluid replacement and vasoactive drugs (initial resuscitation), adequate oxygenation, control of the infection source and an early start of antibiotic therapy, corticosteroid infusion and blood transfusion when properly indicated, prophylaxis, and specifically monitoring and maintenance of fetal heath.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.