ArticleScientific reports2014
Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Understanding Autoimmune Response Mechanisms in Leprosy.Indian dermatology online journal · 2025Article
- Roles of autophagy in killing of mycobacterial pathogens by host macrophages - Effects of some medicinal plants.European journal of microbiology & immunology · 2024Review
- Holothurian triterpene glycoside cucumarioside ACancer cell international · 2023Article
- Mycobacterium intracellulare induces a Th17 immune response via M1-like macrophage polarization in canine peripheral blood mononuclear cells.Scientific reports · 2022Article
- Macrophage Dysfunction in Autoimmune Rheumatic Diseases and Atherosclerosis.International journal of molecular sciences · 2022Review
- Roles of the tissue-type plasminogen activator in immune response.Cellular immunology · 2022Review
- Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition.Matrix biology plus · 2021Article
- Macrophages as a "weapon" in anticancer cellular immunotherapy.The Kaohsiung journal of medical sciences · 2021Review
- Innate immune responses in RNA viral infection.Frontiers of medicine · 2021Review
- Article
- Substrate stiffness directs the phenotype and polarization state of cord blood derived macrophages.Acta biomaterialia · 2021Article
- A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization.iScience · 2021Article
- Criticality of plasma membrane lipids reflects activation state of macrophage cells.Journal of the Royal Society, Interface · 2020Article
- Wear particles induce a new macrophage phenotype with the potential to accelerate material corrosion within total hip replacement interfaces.Acta biomaterialia · 2020Article
- Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking.Scientific reports · 2019Article
- Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Compromised Anti-inflammatory Action of Neutrophil Extracellular Traps in PAD4-Deficient Mice Contributes to Aggravated Acute Inflammation After Myocardial Infarction.Frontiers in immunology · 2019Article
- Aetiological Significance of Infectious Stimuli in Kawasaki Disease.Frontiers in pediatrics · 2019Review
- Transcriptome Profiling of Bovine Macrophages Infected byFrontiers in immunology · 2019Article
- Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization.Stem cell research & therapy · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterial infection induces suppressor macrophages (MΦs), causing disease exacerbation. There are two major MΦ subsets (M1 and M2 MΦs) that are phenotypically and functionally different. Here, we examined which of the MΦ subsets the mycobacterial infection-induced suppressor MΦs (MIS-MΦs) belong to. MIS-MΦs down-regulated T cell production of Th1 and Th2 cytokines but markedly increased production of interleukin (IL)-17A and IL-22 through up-regulation of Th17 cell expansion. In this phenomenon, a novel MΦ population, which is functionally distinguishable from M1 and M2 MΦ subsets and possesses unique phenotypes (IL-12(+), IL-1β(high), IL-6(+), tumor necrosis factor (TNF)-α(+), nitric oxide synthase (NOS) 2(+), CCR7(high), IL-10(high), arginase (Arg)-1(-), mannose receptor (MR)(low), Ym1(high), Fizz(low), and CD163(high)), played central roles through the action of IL-6 and transforming growth factor (TGF)-β but not IL-21 and IL-23. This new type of MΦ population was induced in infected mice and actively supported the in vivo expansion of Th17 cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.