ArticleAmerican journal of physiology. Renal physiology2014
Dominant factors that govern pressure natriuresis in diuresis and antidiuresis: a mathematical model.
Article in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Renal blood flow and oxygenation.Pflugers Archiv : European journal of physiology · 2022Review
- Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling.American journal of physiology. Heart and circulatory physiology · 2019Article
- Mathematical model of hemodynamic mechanisms and consequences of glomerular hypertension in diabetic mice.NPJ systems biology and applications · 2019Article
- SGLT2 inhibition in a kidney with reduced nephron number: modeling and analysis of solute transport and metabolism.American journal of physiology. Renal physiology · 2018Article
- Renal medullary and urinary oxygen tension during cardiopulmonary bypass in the rat.Mathematical medicine and biology : a journal of the IMA · 2017Article
- Sex-specific computational models of the spontaneously hypertensive rat kidneys: factors affecting nitric oxide bioavailability.American journal of physiology. Renal physiology · 2017Article
- A quantitative systems physiology model of renal function and blood pressure regulation: Model description.CPT: pharmacometrics & systems pharmacology · 2017Article
- Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis.American journal of physiology. Renal physiology · 2017Article
- A new microscope for the kidney: mathematics.American journal of physiology. Renal physiology · 2017Article
- Generation and phenotypic analysis of mice lacking all urea transporters.Kidney international · 2017Article
- Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function.American journal of physiology. Renal physiology · 2016Article
- A mathematical model of rat proximal tubule and loop of Henle.American journal of physiology. Renal physiology · 2015Article
- Impacts of nitric oxide and superoxide on renal medullary oxygen transport and urine concentration.American journal of physiology. Renal physiology · 2015Article
- Recent advances in renal hemodynamics: insights from bench experiments and computer simulations.American journal of physiology. Renal physiology · 2015Review
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Authors and funding
2 authors at 1 institution in 2 countries.
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Abstract
We have developed a whole kidney model of the urine concentrating mechanism and renal autoregulation. The model represents the tubuloglomerular feedback (TGF) and myogenic mechanisms, which together affect the resistance of the afferent arteriole and thus glomerular filtration rate. TGF is activated by fluctuations in macula densa [Cl(-)] and the myogefnic mechanism by changes in hydrostatic pressure. The model was used to investigate the relative contributions of medullary blood flow autoregulation and inhibition of transport in the proximal convoluted tubule to pressure natriuresis in both diuresis and antidiuresis. The model predicts that medullary blood flow autoregulation, which only affects the interstitial solute composition in the model, has negligible influence on the rate of NaCl excretion. However, it exerts a significant effect on urine flow, particularly in the antidiuretic kidney. This suggests that interstitial washout has significant implications for the maintenance of hydration status but little direct bearing on salt excretion, and that medullary blood flow may only play a signaling role for stimulating a pressure-natriuresis response. Inhibited reabsorption in the model proximal convoluted tubule is capable of driving pressure natriuresis when the known actions of vasopressin on the collecting duct epithelium are taken into account.
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