ArticleCell cycle (Georgetown, Tex.)2014
Kinetochore microtubule establishment is defective in oocytes from aged mice.
Article in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 93 citations in OpenAlex.
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Tuning Meiotic Checkpoints: Evolutionary Costs and Mechanistic Trade-Offs.Annual review of genetics · 2026Review
- Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes.Nature cell biology · 2025Article
- Chromosome architecture and low cohesion bias acrocentric chromosomes towards aneuploidy during mammalian meiosis.Nature communications · 2024Article
- Hallmarks of female reproductive aging in physiologic aging mice.Nature aging · 2024Review
- Increased DNA damage in full-grown oocytes is correlated with diminished autophagy activation.Nature communications · 2024Article
- The Reproductive Lifespan of Ovarian Follicle.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Oocyte quality is enhanced by hypoglycosylated FSH through increased cell-to-cell interaction during mouse follicle development.Development (Cambridge, England) · 2023Article
- Spindle assembly checkpoint insensitivity allows meiosis-II despite chromosomal defects in aged eggs.EMBO reports · 2023Article
- Twenty years of merotelic kinetochore attachments: a historical perspective.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Review
- Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly.Cell death discovery · 2023Article
- The large cytoplasmic volume of oocyte.The Journal of reproduction and development · 2023Review
- Oocyte Development and Quality in Young and Old Mice following Exposure to Atrazine.Environmental health perspectives · 2022Article
- Oxidative stress induces meiotic defects of oocytes in a mouse psoriasis model.Cell death & disease · 2022Article
- Chromosome Segregation in the Oocyte: What Goes Wrong during Aging.International journal of molecular sciences · 2022Review
- Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction†.Biology of reproduction · 2022Review
- Mechanisms of ovarian aging.Reproduction (Cambridge, England) · 2021Review
- The Molecular Regulation in the Pathophysiology in Ovarian Aging.Aging and disease · 2021Review
- Dysregulated Gene Expression of Imprinted and X-Linked Genes: A Link to Poor Development of Bovine Haploid Androgenetic Embryos.Frontiers in cell and developmental biology · 2021Article
- Molecular basis of reproductive senescence: insights from model organisms.Journal of assisted reproduction and genetics · 2021Review
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3 authors at 2 institutions in 1 country.
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Abstract
Errors in chromosome segregation in mammalian oocytes increase in number with advancing maternal age, and are a major cause of pregnancy loss. Why chromosome segregation errors are more common in oocytes from older females remains poorly understood. In mitosis, accurate chromosome segregation is enabled by attachment of kinetochores to microtubules from appropriate spindle poles, and erroneous attachments increase the likelihood of mis-segregation. Whether attachment errors are responsible for age-related oocyte aneuploidy is unknown. Here we report that oocytes from naturally aged mice exhibit substantially increased chromosome misalignment, and fewer kinetochore pairs that make stable end-on attachments to the appropriate spindle poles compared with younger oocytes. The profile of mis-attachments exhibited is consistent with the types of chromosome segregation error observed in aged oocytes. Loss of chromosome cohesion, which is a feature of oocytes from older females, causes altered kinetochore geometry in meiosis-I. However, this has only a minor impact upon MT attachment, indicating that cohesion loss is not the primary cause of aneuploidy in meiosis-I. In meiosis-II, on the other hand, age-related cohesion loss plays a direct role in errors, since prematurely individualized sister chromatids misalign and misattach to spindle MTs. Thus, whereas cohesion loss leading to precocious sister chromatid separation is a direct cause of errors in meiosis-II, cohesion loss plays a more minor role in the etiology of aneuploidy in meiosis-I. Our data introduce altered MT-kinetochore interactions as a lesion that explains aneuploidy in meiosis-I in older females.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.