ArticleInflammatory bowel diseases2014
Spatial and temporal stability of paneth cell phenotypes in Crohn's disease: implications for prognostic cellular biomarker development.
Article in Inflammatory bowel diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Reactive oxygen species stimulate Paneth cell plasticity and diminish antimicrobial function.The EMBO journal · 2026Article
- Therapeutic zinc targets dysregulated GC-C signaling and restores ileal defects in a preclinical model of familial diarrheal disease.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Cytokine networks in Paneth cell regulation.Mucosal immunology · 2026Review
- Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis.Journal of Crohn's & colitis · 2024Article
- Article
- Infection and inflammation stimulate expansion of a CD74The EMBO journal · 2023Article
- Review
- Ptpn2: A Critical Regulator of Paneth Cell Homeostasis.Cellular and molecular gastroenterology and hepatology · 2023Article
- Article
- Mitochondria and Inflammatory Bowel Diseases: Toward a Stratified Therapeutic Intervention.Annual review of physiology · 2022Review
- Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation.Cell host & microbe · 2021Article
- Article
- Bacterial Translocation as Inflammatory Driver in Crohn's Disease.Frontiers in cell and developmental biology · 2021Review
- The roles and functions of Paneth cells in Crohn's disease: A critical review.Cell proliferation · 2021Review
- Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis.Gut · 2020Article
- Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1.EMBO reports · 2019Article
- Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.The Journal of clinical investigation · 2018Article
- Article
- Paneth Cell Alterations in the Development and Phenotype of Crohn's Disease.Gastroenterology · 2017Article
- Characterization of paneth cells in alpacas (Vicugna pacos, Mammalia, Camelidae).Tissue & cell · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe previously demonstrated that morphologic defects of ileal Paneth cells correlate with multiple susceptible genetic variants, the presence of granuloma, and clinical outcome in Crohn's disease. These studies were performed using uninvolved areas of resection specimens. To develop Paneth cell phenotype as a prognostic biomarker in Crohn's disease, further characterization is necessary. Specifically, effects of disease activity, phenotype duration, and the minimal crypt number that would allow for accurate Paneth cell phenotyping are unknown.
methodsWe compared Paneth cell phenotypes in (1) 46 cases with paired involved and uninvolved sections; (2) 36 cases with multiple ileal resections over time; (3) "virtual biopsies" by randomly selecting 10 to 60 crypts from 85 surgical cases where 250 crypts had been analyzed; and (4) 26 cases with resection and biopsy performed within 1 year.
resultsIn paired resection specimens, the Paneth cell phenotypes in the uninvolved areas correlated with those seen in involved areas (P < 0.0001) and also predicted the presence of granuloma (P = 0.042). Importantly, the Paneth cell phenotype remained stable over time (P < 0.0001). By mathematical analyses, a minimum of 40 crypts was required to generate results equivalent to those using resection specimens. Finally, there was good correlation in Paneth cell phenotypes in biopsy specimens and resection specimens obtained within 1 year (P = 0.0004).
conclusionsAccurate Paneth cell phenotypes can be assessed using biopsy materials with the caveat that sufficient well-oriented crypts exist in the specimen. This advance will extend the potential clinical application of this novel stratification platform.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.