ArticleCell cycle (Georgetown, Tex.)2014
Listeria monocytogenes induces host DNA damage and delays the host cell cycle to promote infection.
Article in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Trypanosoma cruzi infection induces DNA double-strand breaks and activates DNA damage response pathway in host epithelial cells.Scientific reports · 2024Article
- Article
- Lactoferrin as a Human Genome "Guardian"-An Overall Point of View.International journal of molecular sciences · 2022Review
- Histone H3 deacetylation promotes host cell viability for efficient infection by Listeria monocytogenes.PLoS pathogens · 2021Article
- Article
- Tampering of Viruses and Bacteria with Host DNA Repair: Implications for Cellular Transformation.Cancers · 2021Review
- Article
- Article
- Rck ofFrontiers in cellular and infection microbiology · 2020Article
- Stathmin recruits tubulin to Listeria monocytogenes-induced actin comets and promotes bacterial dissemination.Cellular and molecular life sciences : CMLS · 2019Article
- Review
- Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis.Nature reviews. Microbiology · 2018Review
- Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer.Nature reviews. Microbiology · 2017Review
- Subversion of host genome integrity by bacterial pathogens.Nature reviews. Molecular cell biology · 2016Review
- Modulation of p53 during bacterial infections.Nature reviews. Microbiology · 2015Review
- When our genome is targeted by pathogenic bacteria.Cellular and molecular life sciences : CMLS · 2015Review
- Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.Nature communications · 2015Article
- Listeria monocytogenes dampens the DNA damage response.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeria monocytogenes (Lm) is a human intracellular pathogen widely used to uncover the mechanisms evolved by pathogens to establish infection. However, its capacity to perturb the host cell cycle was never reported. We show that Lm infection affects the host cell cycle progression, increasing its overall duration but allowing consecutive rounds of division. A complete Lm infectious cycle induces a S-phase delay accompanied by a slower rate of DNA synthesis and increased levels of host DNA strand breaks. Additionally, DNA damage/replication checkpoint responses are triggered in an Lm dose-dependent manner through the phosphorylation of DNA-PK, H2A.X, and CDC25A and independently from ATM/ATR. While host DNA damage induced exogenously favors Lm dissemination, the override of checkpoint pathways limits infection. We propose that host DNA replication disturbed by Lm infection culminates in DNA strand breaks, triggering DNA damage/replication responses, and ensuring a cell cycle delay that favors Lm propagation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.