ReviewCell cycle (Georgetown, Tex.)2014
Mitochondrial alteration in type 2 diabetes and obesity: an epigenetic link.
Review in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 93 citations in OpenAlex.
- The Potential Target Value of ADP-Ribosylation Factor 6 in Insulin Secretion Regulation and the Treatment of Metabolic Disorders.Metabolites · 2026Review
- FOXO: a key target in regulating aging and age-related diseases.Biogerontology · 2026Review
- Microcystin-LR in drinking water: An emerging role of mitochondrial-induced epigenetic modifications and possible mitigation strategies.Toxicology reports · 2024Review
- Role of Oxidative Stress and Inflammation in Gestational Diabetes Mellitus.Antioxidants (Basel, Switzerland) · 2023Review
- Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized Protein Overload in the Diabetic Rat Brain.Cellular and molecular neurobiology · 2023Article
- Bioinformatics analysis of candidate genes and potential therapeutic drugs targeting adipose tissue in obesity.Adipocyte · 2022Article
- Article
- Humanin and diabetes mellitus: A review ofWorld journal of diabetes · 2022Review
- FoxO transcription factors in mitochondrial homeostasis.The Biochemical journal · 2022Article
- Clinical Characteristics and Management Strategies for Adult Obese Asthma Patients.Journal of asthma and allergy · 2022Review
- Diet normalization or caloric restriction as a preconception care strategy to improve metabolic health and oocyte quality in obese outbred mice.Reproductive biology and endocrinology : RB&E · 2021Article
- The effects of two iso-volume endurance training protocols on mitochondrial dysfunction in type 2 diabetic male mice.Journal of diabetes and metabolic disorders · 2020Article
- Exercise, redox homeostasis and the epigenetic landscape.Redox biology · 2020Review
- Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells.PLoS pathogens · 2020Article
- Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk.The Proceedings of the Nutrition Society · 2019Article
- Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges.International journal of molecular sciences · 2019Review
- Non and Epigenetic Mechanisms in Regulation of Adaptive Thermogenesis in Skeletal Muscle.Frontiers in endocrinology · 2019Article
- Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases.Oxidative medicine and cellular longevity · 2019Review
- MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin.Cardiovascular diabetology · 2018Article
- Epigenetics of Subcellular Structure Functioning in the Origin of Risk or Resilience to Comorbidity of Neuropsychiatric and Cardiometabolic Disorders.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The growing epidemic of type 2 diabetes mellitus (T2DM) and obesity is largely attributed to the current lifestyle of over-consumption and physical inactivity. As the primary platform controlling metabolic and energy homeostasis, mitochondria show aberrant changes in T2DM and obese subjects. While the underlying mechanism is under extensive investigation, epigenetic regulation is now emerging to play an important role in mitochondrial biogenesis, function, and dynamics. In line with lifestyle modifications preventing mitochondrial alterations and metabolic disorders, exercise has been shown to change DNA methylation of the promoter of PGC1α to favor gene expression responsible for mitochondrial biogenesis and function. In this article we discuss the epigenetic mechanism of mitochondrial alteration in T2DM and obesity, and the effects of lifestyle on epigenetic regulation. Future studies designed to further explore and integrate the epigenetic mechanisms with lifestyle modification may lead to interdisciplinary interventions and novel preventive options for mitochondrial alteration and metabolic disorders.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.