ReviewNature reviews. Neuroscience2014
Hippocampal synaptic plasticity, spatial memory and anxiety.
Review in Nature reviews. Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 326 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
326 citing papers in PubMed, 2 syntheses or guidelines pooled it, 679 citations in OpenAlex.
- Efficacy and mechanism of acupuncture in animal models of depressive-like behaviors: a systematic review and meta-analysis.Frontiers in neuroscience · 2024Pooled it
- The microbiota-gut- hippocampus axis.Frontiers in neuroscience · 2022Pooled it
- Anterior hippocampal volume predicts affect-focused psychotherapy outcome.Psychological medicine · 2020Trial
- Sex differences in human deep grey matter microstructure emerge during adolescence.Developmental cognitive neuroscience · 2026Article
- Methylglyoxal mildly impairs spatial memory and reduces expression of excitatory synaptic genes in the hippocampus of male mice.Physiological reports · 2026Article
- Glycolysis-enhancing αAlzheimer's research & therapy · 2026Article
- Article
- Prenatal cannabinoid exposure alters excitation-inhibition balance through glutamate and GABA receptor-mediated signaling.The Journal of biological chemistry · 2026Article
- Sex- and Region-Dependent Differences in Sharp Wave-Ripples Along the Long Axis of the Hippocampus.Cells · 2026Article
- Differential atrophy along the longitudinal axis of the hippocampus in Alzheimer's disease and suspected non-Alzheimer's disease pathophysiology (SNAP).Neuroradiology · 2026Article
- Investigating the Dynamic Relationship Between Anxiety and Spatial Memory Using Autonomous Ecological Momentary Assessment.Research square · 2026Article
- Osteocalcin is a compensatory hormone to protect the nervous system in ovariectomized mice.npj aging · 2026Article
- ARHGAP39 plays an essential role in anxiety-like behavior and stress response.Translational psychiatry · 2026Article
- Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice.The EMBO journal · 2026Article
- Prenatal exposure to particulate matter impairs offspring behavior via hippocampal NMDA receptor reduction: an in vivo and ex vivo study.Environment international · 2026Article
- Hyper-maturity and accelerated aging in the hippocampus of mouse models of neuropsychiatric disorders with anxiety-like behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Sex-dependent cognitive and behavioral outcomes induced by repetitive cortical spreading depression in mice.The journal of headache and pain · 2026Article
- Morphological changes in microglia in the mouse brain during postnatal development and obesity.Histology and histopathology · 2026Article
- Organic Phototransistor Photonic Synapses for Artificial Vision.Nano-micro letters · 2026Review
- Distinct orbitofrontal circuits with dorsal and ventral CA1 differentially regulate spatial memory and emotional behaviors.Frontiers in behavioral neuroscience · 2026Article
266 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.