Evidence map›Paper›PMID 24552754›Full record

Observational studyThe American journal of clinical nutrition2014

Sugars and risk of mortality in the NIH-AARP Diet and Health Study.

Natasha Tasevska, Yikyung Park, Li Jiao, Albert Hollenbeck, Amy F Subar, Nancy Potischman

2 registry-linked trialsAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00340015 completednot on this map

NCI-AARP Diet and Health Study

TypeobservationalSponsorNational Cancer Institute (NCI)Ran1995 to 2015Enrolled566,401ConditionsDeath, Cancer
NCT02719626 completednot on this map

Improving The Safety And Nutritional Adequacy Of The Home Food Supply Of Elderly Recipients Of Home Delivered Meals

TypeobservationalSponsorRutgers, The State University of New JerseyRan2011 to 2013Enrolled740ConditionsFood Safety, Nutritive Value, Homebound Persons, Frail Elderly
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Trial
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Prospective Cohort of Pre- and Post-Diagnosis Diet with Survival Outcomes: an Alberta Endometrial Cancer Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Tolerable upper intake level for dietary sugars.EFSA journal. European Food Safety Authority · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Natasha TasevskaApplied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, MD (NT, AFS, and NP); the Nutrition Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ (NT); the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD (YP and LJ); the Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX (LJ); and the AARP, Washington, DC (AH).
Yikyung Park
Li Jiao
Albert Hollenbeck
Amy F Subar
Nancy Potischman

Funding

Prospective Studies of Diet and Cancer in the AARP CohortZIACP010196 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SINHA, RASHMI · 2009 to 2025
$21.0M
Intramural NIH HHS
6 · The paper itself

Abstract

backgroundAlthough previous studies have linked intake of sugars with incidence of cancer and other chronic diseases, its association with mortality remains unknown.

objectiveWe investigated the association of total sugars, added sugars, total fructose, added fructose, sucrose, and added sucrose with the risk of all-cause, cardiovascular disease, cancer, and other-cause mortality in the NIH-AARP Diet and Health Study.

designThe participants (n = 353,751), aged 50-71 y, were followed for up to 13 y. Intake of individual sugars over the previous 12 mo was assessed at baseline by using a 124-item NIH Diet History Questionnaire.

resultsIn fully adjusted models (fifth quartile compared with first quartile), all-cause mortality was positively associated with the intake of total sugars [HR (95% CI): 1.13 (1.06, 1.20); P-trend < 0.0001], total fructose [1.10 (1.04, 1.17); P-trend < 0.0001], and added fructose [1.07 (1.01, 1.13); P-trend = 0.005) in women and total fructose [1.06 (1.01, 1.10); P-trend = 0.002] in men. In men, a weak inverse association was found between other-cause mortality and dietary added sugars (P-trend = 0.04), sucrose (P-trend = 0.03), and added sucrose (P-trend = 0.006). Investigation of consumption of sugars by source showed that the positive association with mortality risk was confined only to sugars from beverages, whereas the inverse association was confined to sugars from solid foods.

conclusionsIn this large prospective study, total fructose intake was weakly positively associated with all-cause mortality in both women and men, whereas added sugar, sucrose, and added sucrose intakes were inversely associated with other-cause mortality in men. In our analyses, intake of added sugars was not associated with an increased risk of mortality. The NIH-AARP Diet and Health Study was registered at clinicaltrials.gov as NCT00340015.

Indexed as

DietAgedBody Mass IndexCardiovascular DiseasesDietary SucroseFemaleFollow-Up StudiesFructoseHumansMaleMiddle AgedMultivariate AnalysisNeoplasmsNutrition AssessmentProportional Hazards ModelsSucroseDietary SucroseFructoseSucrose

Identifiers

PMID24552754
PMCPMC3985213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.