ArticleJournal of clinical hypertension (Greenwich, Conn.)2014
Orthostatic blood pressure dysregulation and polymorphisms of β-adrenergic receptor genes in hypertensive patients.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Analysis of adenylate cyclase activity in Japanese children with orthostatic dysregulation.PloS one · 2026Article
- Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children.Metabolites · 2023Review
- Monoamino oxidase alleles correlate with the presence of essential hypertension among hypogonadic patients.Molecular genetics & genomic medicine · 2020Article
- Genomics of Cardiovascular Measures of Autonomic Tone.Journal of cardiovascular pharmacology · 2018Review
- Arterial Stiffness, Central Pulsatile Hemodynamic Load, and Orthostatic Hypotension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Neuroendocrinological and Epigenetic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic Syndrome.Frontiers in neuroscience · 2016Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic susceptibility to orthostatic blood pressure dysregulation remains poorly understood. The association between polymorphisms of beta-adrenergic receptor (β-AR) genes and orthostatic blood pressure dysregulation in hypertensive patients was investigated. Two polymorphisms of β1 -AR (Arg389/Gly) and β2 -AR (Arg16/Gly) were genotyped in untreated hypertensive patients and normotensive patients. In patients with untreated hypertension, the frequency of β1 -AR Gly389 homozygote was significantly higher in patients with orthostatic hypotension (OH) (P<.0001) and lower in patients with orthostatic hypertension (OHT) (P=.002) as compared with patients with orthostatic normotension (ONT) even after Bonferroni correction. After analysis by sex and adjustment for conventional risk factors, the β1 -AR Gly389 homozygote conferred about a 3-fold risk of OH and independently predicted a 6.5 mm Hg greater orthostatic SBP decrease (GG -8.9±13 mm Hg vs CC+CG -2.4±12 mm Hg, P<.001) only in female hypertensive patients. The association of β2 -AR Arg16/Gly with OH was not significant after adjustment for conventional risk factors. In normotensive patients, no association was identified between these two polymorphisms and OHT or OH. These results indicated that the β1 -AR Arg389/Gly polymorphism may be associated with increased risk of OH in female hypertensive patients.
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