Evidence map›Paper›PMID 24551847›Full record

ArticleBioMed research international2014

Cell surface proteomics analysis indicates a neural lineage bias of rat bone marrow mesenchymal stromal cells.

Guiyun Zhao, Huijiao Ji, Shihao Wang, Bin Gu, Xiuli Song, Jiarong Zhang, Yukan Liu, Liangbiao Chen, Ming Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Guiyun ZhaoThe Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Huijiao JiThe Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Shihao WangThe Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-9445-5951
Bin GuThe Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-9543-5450
Xiuli SongThe Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Jiarong ZhangThe Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-0953-2455
Yukan LiuThe Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Liangbiao ChenKey Laboratory of Aquatic Resources and Utilization, Ministry of Education, College of Fisheries and Life Sciences, Shanghai Ocean University, Shanghai, 201306, China.
Ming ZhangThe Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Zhejiang University · CNShanghai Ocean University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stromal cells (MSCs) are one of the most intensively studied stem cell types with application aims. However, the molecular characterisation and the relationship between the molecular characterisation and functional properties of MSCs are largely unknown. In this study, we purified the surface proteins from rat bone marrow MSCs (rBMMSCs) and characterised their surface proteome by LC-MS/MS. Moreover, we comparatively analysed the data from this study with the surface proteomics data of mouse and human embryonic stem (ES) cells and human mesenchymal stromal cells (hMSCs). The data showed that, in contrast to ES cells and human mesenchymal stromal cells, rBMMSCs possessed a surface proteomics pattern biased to neural and neural-endocrine lineages, indicating a neural/neural crest bias, and suggested a neural differentiation tendency of these cells. The different surface proteomics pattern between rBMMSCs and hMSCs also suggested that MSCs of different origin might possess a different lineage bias.

Indexed as

ProteomicsAnimalsBone Marrow CellsCell DifferentiationCell LineageGene Expression Regulation, DevelopmentalHumansMembrane ProteinsMesenchymal Stem CellsMiceNeuronsOsteogenesisRatsMembrane Proteins

Identifiers

PMID24551847
PMCPMC3914342
OpenAlexW2077716130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.