ArticleInternational journal of molecular and cellular medicine2013
C - reactive protein levels in patients with periodontal disease and normal subjects.
Article in International journal of molecular and cellular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06627972 (IS THERE A RELATIONSHIP BETWEEN PERIODONTAL CONDITION AND ASPROSIN LEVEL IN GINGIVAL CREVICULAR FLUID?), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is there a relationship between periodontal condition and asprosin level in gingival crevicular fluid?
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Potential of Saliva in Stroke Patients: A Review.International journal of molecular sciences · 2026Review
- Biosensors in dental, oral and craniofacial applications.Npj biosensing · 2026Review
- Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum?BMC oral health · 2025Observational
- The Influence of Depression on Gingival Health and C-Reactive Protein Among Female Students in Iraq: A Cross-Sectional Study.Clinical, cosmetic and investigational dentistry · 2025Article
- Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review.Microorganisms · 2024Review
- The association between dental caries and serum crp in the us adult population: evidence from NHANES 2015-2018.BMC public health · 2024Article
- Salivary levels of inflammatory and anti-inflammatory biomarkers in periodontitis patients with and without acute myocardial infarction: implications for cardiovascular risk assessment.Frontiers in oral health · 2024Article
- The utility of salivary CRP and IL-6 as a non-invasive measurement evaluated in patients with COVID-19 with and without diabetes.F1000Research · 2023Article
- Detection of soluble urokinase type plasminogen activator receptors in children with gingivitis and normal subjects.BMC oral health · 2022Observational
- The Role of Salivary C-Reactive Protein in Systemic and Oral Disorders: A Systematic Review.Medical journal of the Islamic Republic of Iran · 2022Review
- Expression of Inflammatory Mediators in Periodontitis Over Established Diabetes: an Experimental Study in Rats.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2021Article
- Plasma 25-Hydroxyvitamin D Concentrations and Serum and Salivary C-Reactive Protein in the Osteoporosis and Periodontal Disease Study.Nutrients · 2021Article
- Diagnostic Models for Screening of Periodontitis with Inflammatory Mediators and Microbial Profiles in Saliva.Diagnostics (Basel, Switzerland) · 2020Article
- Nonsurgical Periodontal Therapy Reduces Salivary and Gingival Crevicular Fluid YKL-40 and IL-6 Levels in Chronic Periodontitis.Oral health & preventive dentistry · 2020Article
- Characterizing the Subgingival Microbiome of Pregnant African American Women.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2019Article
- Diagnostic value of salivary CRP and IL-6 in patients undergoing anti-TNF-alpha therapy for rheumatic disease.Inflammopharmacology · 2018Article
- Salivary and serum adiponectin and C-reactive protein levels in acute myocardial infarction related to body mass index and oral health.Journal of periodontal research · 2017Article
- Relationship between Gingival Crevicular Fluid Microbiota and Cytokine Profile in Periodontal Host Homeostasis.Frontiers in microbiology · 2017Article
- Salivary inflammatory markers and microbiome in normoglycemic lean and obese children compared to obese children with type 2 diabetes.PloS one · 2017Article
- C-Reactive Protein in Peripheral Blood of Patients with Chronic and Aggressive Periodontitis, Gingivitis, and Gingival Recessions.Mediators of inflammation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although periodontitis is a chronic inflammatory disease but some factors of acute inflammation phase are involved in this disease among which is the C-Reactive protein (CRP). To minimize its effects, anti-inflammatory drugs or non-pharmacological approaches such as oral hygiene is recommended. CRP can also be used for the prediction and early detection of periodontal disease. The aim of the present study was the comparison of the amount of salivary C-Reactive protein (CRP) in healthy subjects and patients with periodontal disease. This case-control study was done on 90 patients referred to the Department of Periodontology of Babol Dentistry School. These subjects were divided into three groups of healthy (n = 30), gingivitis (n = 30), and chronic periodontitis (n = 30), based on Gingival Index (GI) and Clinical Attachment Loss (CAL) indices. 2ml saliva samples were collected from these people and clinical indicators including GI, CAL, Periodontal Pocket Depth (PPD), and Bleeding Index (BI) were assessed. ELISA method was used to evaluate the salivary CRP levels. Collected data were analyzed using SPSS statistical software by non-Parametric Kruskal-Wallis and Mann-Whitney test and Spearman correlation coefficient and P<0.05 was considered significant. The mean salivary CRP levels were 5332.62±5051.63pg/ml in periodontitis patients, 3545.41±3061.38pg/ml in gingivitis group and 3108.51±3574.47pg/ml in healthy subjects. The statistic analysis showed a significant difference in salivary CRP concentrations between the periodontitis patients and healthy subjects (P=0.045). The results indicate that there is a significant association between periodontitis and salivary CRP concentrations.
Indexed as
Identifiers
24551806PMC3920533W2157641853What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.