A comparative study of PCNA and Ki-67 expression in dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma.

Shima Nafarzadeh, Maryam Seyedmajidi, Sina Jafari, Ali Bijani, Ali Rostami-Sarokolaei

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In one paragraph

Article in International journal of molecular and cellular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it

0cells of the map it votes in

10citing papers in PubMed

1.3field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review.Diagnostics (Basel, Switzerland) · 2024
Review
LncRNA LIFR-AS1 overexpression suppressed the progression of serous ovarian carcinoma.Journal of clinical laboratory analysis · 2022
Article
Histopathologic spectrum and clinical correlation of lesions of jaw - a series of 60 cases.International journal of clinical and experimental pathology · 2022
Article
Shark tooth regeneration reveals common stem cell characters in both human rested lamina and ameloblastoma.Scientific reports · 2019
Article
Calcifying odontogenic cyst: A 26-year retrospective clinicopathological analysis and immunohistochemical study.Journal of clinical and experimental dentistry · 2018
Article
Clinicopathological and cell proliferation evaluation of ameloblastomas and keratocystic odontogenic tumors: a 10 year retrospective study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
Article
Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas.Analytical cellular pathology (Amsterdam) · 2016
Article
Immunohistochemical expression of osteonectin, matrix metalloproteinases-9 and Ki-67 in ameloblastoma.Journal of oral and maxillofacial pathology : JOMFP
Article
Proliferative and anti-apoptotic indices of unicystic ameloblastoma, odontogenic keratocyst, dentigerous cyst and radicular cyst.Journal of oral and maxillofacial pathology : JOMFP
Article
MCM3 and Ki67 proliferation markers in odontogenic cysts and ameloblastoma.Journal of oral biology and craniofacial research
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shima NafarzadehDental material research center, Babol University of Medical Sciences, Babol, Iran. ; Department of Oral and Maxillofacial Pathology, Dentistry school, Babol University of Medical Sciences, Babol, Iran.

Maryam SeyedmajidiDental material research center, Babol University of Medical Sciences, Babol, Iran. ; Department of Oral and Maxillofacial Pathology, Dentistry school, Babol University of Medical Sciences, Babol, Iran.

Sina JafariStudent Research Committee, Babol University of Medical Sciences, Babol, Iran.

Ali BijaniNon-communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran.

Ali Rostami-SarokolaeiDentistry school, Babol University of Medical Sciences, Babol, Iran.

Babol University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various cell proliferation markers are used as diagnostic and prognostic tools in oral lesions. Simultaneous evaluation of these markers can increase the precision of estimation of the proliferative status of different tissues. In this study we investigated the expression of PCNA and Ki-67 as markers of cell proliferation in 15 paraffin embedded samples of each dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma belonging to a total of 30 male and 30 female paients using immunohistochemistry method. Expression levels based on the intensity and the percentage of stained cells was separately analyzed for each marker with chi-square test, the results of which were significant for the two markers (P<0.05). The correlation coefficient between the two markers was found to be 0.88. A significant difference in the expression of Ki-67 and PCNA was observed in the four types of studied lesions.

Indexed as

ameloblastomadental follicledentigerous cystimmunohistochemistryKi-67PCNA

Identifiers

PMID24551787

PMCPMC3920517

OpenAlexW2125024026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.