Evidence map›Paper›PMID 24551621›Full record

ArticleJournal of clinical and diagnostic research : JCDR2013

Circulating Serotypes and Trends in Antibiotic Resistance of Invasive Streptococcus Pneumoniae from Children under Five in Bangalore.

Ravi Kumar K L, Feroze Ganaie, Vandana Ashok

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Article in Journal of clinical and diagnostic research : JCDR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
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8citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Ravi Kumar K LProfessor & Head, Department of Microbiology, Kempegowda Institute of Medical Sciences Hospital & Research Centre , Bangalore-560004, India .
Feroze GanaieSenior Research Fellow, Department of Microbiology, Kempegowda Institute of Medical Sciences Hospital & Research Centre , Bangalore-560004, India .
Vandana AshokSenior Research Fellow, Department of Microbiology, Kempegowda Institute of Medical Sciences Hospital & Research Centre , Bangalore-560004, India .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlobally, Streptococcus pneumoniae is estimated to be responsible for 1 to 2 million deaths annually, in extremes of age. Serotypic distribution of pneumococci varies with age, time, and geographical area. Limited data is available on serotypic prevalence and antimicrobial susceptibility patterns of pneumococci in India.

aimTo assess resistance trends to different groups of antimicrobials and serotypic prevalences of invasive pneumococci. SETTINGS AND

designA prospective, hospital based study was conducted for two years, at a tertiary care medical college hospital in south Bangalore. Forty invasive pneumococcal isolates from children who were ≤5 years, with a clinical and radiological diagnosis of invasive pneumococcal disease, (IPD) were evaluated.

methodsQualitative typing/grouping was performed by doing the capsular reaction test (Neufeld test). Antimicrobial susceptibility was tested by Minimum Inhibitory Concentration method using automated microdilution procedure.

resultsThe predominant invasive pneumococcal serotypes were serogroups/types (SGTs) 6 (25%) and 14 (17.5%). 35%, 77.5% and 15% of isolates were resistant to Penicillin, Trimethoprim/Sulfamethoxazole (TMP-SMX) and Ceftriaxone respectively. Intermediate and high level resistances to penicillin were seen in 22.5% and 12.5% of S. pneumoniae isolates correspondingly. Multidrug resistance was observed in 20% of strains.

conclusionThis study reported presence of high level drug resistance in invasive pneumococcal isolates which were obtained from children. The serogroup/type distribution in our study and those in other Indian studies were not even. This calls for monitoring of resistance and mapping of serotype distribution.

Indexed as

Drug resistanceInvasive pneumococcal diseaseSerotypesStreptococcus pneumoniae

Identifiers

PMID24551621
PMCPMC3919300

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