ReviewFrontiers in cellular and infection microbiology2014
Pathogenic adaptations to host-derived antibacterial copper.
Review in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 132 citations in OpenAlex.
- Antibacterial and antioxidant okra-based hydrogels enhanced with Ag@HKUST-1 as a next-generation wound dressing.International journal of pharmaceutics: X · 2026Article
- Targeting Ferroptosis and Cuproptosis for Antimicrobial Control in Postharvest Preservation.Comprehensive reviews in food science and food safety · 2026Review
- Fabrication of Chondroitin Sulfate-Copper/Zinc Complexes and Antibacterial Activity Involving Hydrogel Application in Infected Wound Healing.Gels (Basel, Switzerland) · 2026Article
- Review
- The importance of zinc, copper and manganese and their impact on growth, immunity and fertility of male cattle: a review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- Characterization of the Antibiotic and Copper Resistance of Emergent Species of Onion-PathogenicPathogens (Basel, Switzerland) · 2025Article
- A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Antibacterial Properties of Copper Oxide Nanoparticles (Review).International journal of molecular sciences · 2024Review
- Unraveling the Role of Metals and Organic Acids in Bacterial Antimicrobial Resistance in the Food Chain.Antibiotics (Basel, Switzerland) · 2023Review
- Linking Copper-Associated Signal Transduction Systems with Their Environment in Marine Bacteria.Microorganisms · 2023Review
- In vitro and in vivo investigation of chrysin chelated copper complex as biocompatible materials for bone tissue engineering applications.3 Biotech · 2023Article
- Article
- Enhanced antibacterial behavior of a novel Cu-bearing high-entropy alloy.Journal of materials science & technology · 2022Article
- ThemBio · 2022Article
- Cu(ii)-based DNA labeling identifies the structural link between transcriptional activation and termination in a metalloregulator.Chemical science · 2022Article
- The progress in titanium alloys used as biomedical implants: From the view of reactive oxygen species.Frontiers in bioengineering and biotechnology · 2022Review
- Copper Metabolism inFrontiers in cell and developmental biology · 2022Article
- Copper Homeostatic Mechanisms and Their Role in the Virulence of Escherichia coli and Salmonella enterica.EcoSal Plus · 2021Review
- Article
- Whole Genome Sequencing of Methicillin-ResistantMicroorganisms · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent findings suggest that both host and pathogen manipulate copper content in infected host niches during infections. In this review, we summarize recent developments that implicate copper resistance as an important determinant of bacterial fitness at the host-pathogen interface. An essential mammalian nutrient, copper cycles between copper (I) (Cu(+)) in its reduced form and copper (II) (Cu(2+)) in its oxidized form under physiologic conditions. Cu(+) is significantly more bactericidal than Cu(2+) due to its ability to freely penetrate bacterial membranes and inactivate intracellular iron-sulfur clusters. Copper ions can also catalyze reactive oxygen species (ROS) generation, which may further contribute to their toxicity. Transporters, chaperones, redox proteins, receptors and transcription factors and even siderophores affect copper accumulation and distribution in both pathogenic microbes and their human hosts. This review will briefly cover evidence for copper as a mammalian antibacterial effector, the possible reasons for this toxicity, and pathogenic resistance mechanisms directed against it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.