ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2013
Semantic MEDLINE for discovery browsing: using semantic predications and the literature-based discovery paradigm to elucidate a mechanism for the obesity paradox.
Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Drug repurposing for COVID-19 via knowledge graph completion.Journal of biomedical informatics · 2021Article
- Using Literature Based Discovery to Gain Insights Into the Metabolomic Processes of Cardiac Arrest.Frontiers in research metrics and analytics · 2021Article
- Broad-coverage biomedical relation extraction with SemRep.BMC bioinformatics · 2020Article
- Influence of Diabetic Retinopathy on the Relationship Between Body Mass Index and Mortality in Patients with Poorly Controlled Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- BEERE: a web server for biomedical entity expansion, ranking and explorations.Nucleic acids research · 2019Article
- SemNet: Using Local Features to Navigate the Biomedical Concept Graph.Frontiers in bioengineering and biotechnology · 2019Article
- A Literature Based Discovery Visualization System with Hierarchical Clustering and Linking Set Associations.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019Article
- Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing.Journal of biomedical semantics · 2018Article
- Biomedical text mining for research rigor and integrity: tasks, challenges, directions.Briefings in bioinformatics · 2018Article
- Rediscovering Don Swanson: the Past, Present and Future of Literature-Based Discovery.Journal of data and information science (Warsaw, Poland) · 2017Article
- Informatics Support for Basic Research in Biomedicine.ILAR journal · 2017Review
- Context-driven automatic subgraph creation for literature-based discovery.Journal of biomedical informatics · 2015Article
- Operationalizing Semantic Medline for meeting the information needs at point of care.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2015Article
- Networks of neuroinjury semantic predications to identify biomarkers for mild traumatic brain injury.Journal of biomedical semantics · 2015Article
- Development and application of an interaction network ontology for literature mining of vaccine-associated gene-gene interactions.Journal of biomedical semantics · 2015Article
- Applying MetaMap to Medline for identifying novel associations in a large clinical dataset: a feasibility analysis.Journal of the American Medical Informatics Association : JAMIAArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Applying the principles of literature-based discovery (LBD), we elucidate the paradox that obesity is beneficial in critical care despite contributing to disease generally. Our approach enhances a previous extension to LBD, called "discovery browsing," and is implemented using Semantic MEDLINE, which summarizes the results of a PubMed search into an interactive graph of semantic predications. The methodology allows a user to construct argumentation underpinning an answer to a biomedical question by engaging the user in an iterative process between system output and user knowledge. Components of the Semantic MEDLINE output graph identified as "interesting" by the user both contribute to subsequent searches and are constructed into a logical chain of relationships constituting an explanatory network in answer to the initial question. Based on this methodology we suggest that phthalates leached from plastic in critical care interventions activate PPAR gamma, which is anti-inflammatory and abundant in obese patients.
Indexed as
Identifiers
24551329PMC3900170W85744764What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.