ArticleInternational journal of clinical and experimental pathology2014
Exercise-induced physiological hypertrophy initiates activation of cardiac progenitor cells.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026Review
- Comparison of the effect of eight weeks of Rhythmic aerobic training and CX-WORX on cholesterol transport and inflammatory factors in obese women.Journal of education and health promotion · 2026Article
- Article
- Review
- Effect of Taichi-oriented exercise rehabilitation on the quality of life of patients with acute myocardial infarction after interventional therapy: a retrospective study.American journal of translational research · 2022Article
- Physical Exercise: A Novel Tool to Protect Mitochondrial Health.Frontiers in physiology · 2021Review
- Cardioprotection in right heart failure.British journal of pharmacology · 2020Review
- Effects of physical exercise on the prevention of stem cells senescence.Stem cell reviews and reports · 2020Review
- Energy Metabolism in Exercise-Induced Physiologic Cardiac Hypertrophy.Frontiers in pharmacology · 2020Review
- Downregulation of miR-26b-5p, miR-204-5p, and miR-497-3p Expression Facilitates Exercise-Induced Physiological Cardiac Hypertrophy by Augmenting Autophagy in Rats.Frontiers in genetics · 2020Article
- One year of exercise training promotes distinct adaptations in right and left ventricle of female Sprague-Dawley rats.Journal of physiology and biochemistry · 2019Article
- Physiological Responses to Swimming-Induced Exercise in the Adult Zebrafish Regenerating Heart.Frontiers in physiology · 2018Article
- Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling.Frontiers in cardiovascular medicine · 2018Review
- The Role of MicroRNAs in the Cardiac Response to Exercise.Cold Spring Harbor perspectives in medicine · 2017Review
- Cardiac cell proliferation is not necessary for exercise-induced cardiac growth but required for its protection against ischaemia/reperfusion injury.Journal of cellular and molecular medicine · 2017Article
- Telocytes in exercise-induced cardiac growth.Journal of cellular and molecular medicine · 2016Article
- Pathological Left Ventricular Hypertrophy and Stem Cells: Current Evidence and New Perspectives.Stem cells international · 2016Review
- Using exercise to measure and modify cardiac function.Cell metabolism · 2015Review
- Origin of cardiomyocytes in the adult heart.Circulation research · 2015Review
- Exercise Prevention of Cardiovascular Disease in Breast Cancer Survivors.Journal of oncology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePhysiological hypertrophy is featured by the hypertrophy of pre-existing cardiomyocytes and the formation of new cardiomyocytes. C-kit positive cardiac progenitor cells increased their numbers in exercise-induced physiological hypertrophy. However, the participation of Sca-1 positive cells in the physiological adaptation of the heart to exercise training is unclear.
methodsPhysiological hypertrophy was induced by swimming and the mRNA levels of GATA binding protein 4 (GATA4), atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), endogenous hepatocyte growth factor (HGF), and insulin like growth factor-1 (IGF-1) from the whole heart were determined by real-time polymerase chain reactions (RT-PCRs) analysis. Immunofluorescent staining was used to compare the number of C-kit and Sca-1 positive cardiac progenitor cells. In addition, mRNA levels of C-kit and Sca-1 in left ventricle (LV), right ventricle (RV), and outflow tract (OFT) were determined in mice swimming for 7, 14, and 21 days by RT-PCRs.
resultsThe ratio of heart weight (HW) to body weight and HW to tibia length and the mRNA level of GATA4 were increased while mRNA levels of ANP and BNP remained unchanged. C-kit and Sca-1 positive cardiac progenitor cells were activated by swimming training. An increased endogenous production of HGF and IGF was observed at least at the mRNA level. Swimming induced a significant up-regulation of C-kit in LV of mice swimming for 1, 2 and 3 weeks and in RV of mice swimming for 3 weeks. Sca-1 positive cardiac progenitor cells were increased in LV and OFT in mice swimming for 3 weeks.
conclusionThis study presents that swimming-induced physiological hypertrophy initiates activation of cardiac progenitor cells.
Indexed as
Identifiers
24551287PMC3925911W2210619896What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.