ArticlePloS one2014
Characterisation of dendritic cells arising from progenitors endogenous to murine spleen.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Skeletal stem/progenitor cells provide the niche for extramedullary hematopoiesis in spleen.Frontiers in physiology · 2023Article
- The adjuvant effect of bacterium-like particles depends on the route of administration.Frontiers in immunology · 2023Article
- Extramedullary hematopoiesis: mesenchymal stromal cells from spleen provide an in vitro niche for myelopoiesis.In vitro cellular & developmental biology. Animal · 2022Article
- Role of SVEP1 in Stroma-Dependent HematopoiesisFrontiers in cell and developmental biology · 2021Article
- A novel myeloid cell in murine spleen defined through gene profiling.Journal of cellular and molecular medicine · 2019Article
- Transplanted spleen stromal cells with osteogenic potential support ectopic myelopoiesis.PloS one · 2019Article
- Identification of Stromal Cells in Spleen Which Support Myelopoiesis.Frontiers in cell and developmental biology · 2019Article
- MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis.BMC immunology · 2018Article
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- Impact of the c-MybE308G mutation on mouse myelopoiesis and dendritic cell development.PloS one · 2017Article
- An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Delineation of a novel dendritic-like subset in human spleen.Cellular & molecular immunology · 2016Article
- Redefining Myeloid Cell Subsets in Murine Spleen.Frontiers in immunology · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterogeneity amongst dendritic cell (DC) subsets leads to a spectrum of immune response capacity against pathogens. Several DC subsets in spleen have been described which differ in terms of phenotype and function. We have previously reported a distinct population of CD11c(lo)CD11b(hi)MHC-II(-)CD8(-) dendritic-like "L-DC" in murine spleen, which can also be generated in splenic stromal longterm cultures. Here, the ontogeny of L-DC development in perinatal mice has been compared with other known splenic DC subsets. Flow cytometric analysis has revealed the presence of L-DC at embryonic age (E)18.5 spleen, while plasmacytoid (p)DC and conventional (c)DC appear at 2 and 4 days following birth. Co-cultures of E18.5 spleen above splenic stroma also showed production of only L-DC, while spleen cells from D0 through D5 neonates showed production of both L-DC and cDC-like cells. Addition of an M-CSFR inhibitor to co-cultures revealed that while the development of cDC-like cells depended on M-CSF, many L-DC developed independently of M-CSF. Furthermore, purified hematopoietic stem cells (HSC) and multipotential progenitors (MPP) isolated from neonatal D1 spleen are capable of developing into L-DC in co-cultures. These studies reveal a lineage of dendritic-like cells developing in the spleen microenvironment, and which appear to arise from endogenous progenitors laid down in spleen during embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.