ArticlePloS one2014
Spatiotemporal characterizations of dengue virus in mainland China: insights into the whole genome from 1978 to 2011.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Beneath the surface: Amino acid variation underlying two decades of dengue virus antigenic dynamics in Bangkok, Thailand.PLoS pathogens · 2022Article
- Three highly variable genome regions of the four dengue virus serotypes can accurately recapitulate the CDS phylogeny.MethodsX · 2022Article
- Emergence of Zika Virus in Culex tritaeniorhynchus and Anopheles sinensis Mosquitoes in China.Virologica Sinica · 2021Article
- Development of a Standardized Sanger-Based Method for Partial Sequencing and Genotyping of Dengue Viruses.Journal of clinical microbiology · 2019Article
- Flavivirus and Filovirus EvoPrinters: New alignment tools for the comparative analysis of viral evolution.PLoS neglected tropical diseases · 2017Article
- Climate variation drives dengue dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Effective Protection Induced by a Monovalent DNA Vaccine against Dengue Virus (DV) Serotype 1 and a Bivalent DNA Vaccine against DV1 and DV2 in Mice.Frontiers in cellular and infection microbiology · 2017Article
- The Effects of Socioeconomic and Environmental Factors on the Incidence of Dengue Fever in the Pearl River Delta, China, 2013.PLoS neglected tropical diseases · 2015Article
- Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Temporal-Spatial of dengue virus (DENV) analyses have been performed in previous epidemiological studies in mainland China, but few studies have examined the whole genome of the DENV. Herein, 40 whole genome sequences of DENVs isolated from mainland China were downloaded from GenBank. Phylogenetic analyses and evolutionary distances of the dengue serotypes 1 and 2 were calculated using 14 maximum likelihood trees created from individual genes and whole genome. Amino acid variations were also analyzed in the 40 sequences that included dengue serotypes 1, 2, 3 and 4, and they were grouped according to temporal and spatial differences. The results showed that none of the phylogenetic trees created from each individual gene were similar to the trees created using the complete genome and the evolutionary distances were variable with each individual gene. The number of amino acid variations was significantly different (p = 0.015) between DENV-1 and DENV-2 after 2001; seven mutations, the N290D, L402F and A473T mutations in the E gene region and the R101K, G105R, D340E and L349M mutations in the NS1 region of DENV-1, had significant substitutions, compared to the amino acids of DENV-2. Based on the spatial distribution using Guangzhou, including Foshan, as the indigenous area and the other regions as expanding areas, significant differences in the number of amino acid variations in the NS3 (p = 0.03) and NS1 (p = 0.024) regions and the NS2B (p = 0.016) and NS3 (p = 0.042) regions were found in DENV-1 and DENV-2. Recombination analysis showed no inter-serotype recombination events between the DENV-1 and DENV-2, while six and seven breakpoints were found in DENV-1 and DENV-2. Conclusively, the individual genes might not be suitable to analyze the evolution and selection pressure isolated in mainland China; the mutations in the amino acid residues in the E, NS1 and NS3 regions may play important roles in DENV-1 and DENV-2 epidemics.
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