Evidence map›Paper›PMID 24551055›Full record

SynthesisPloS one2014

P300 development across the lifespan: a systematic review and meta-analysis.

Rik van Dinteren, Martijn Arns, Marijtje L A Jongsma, Roy P C Kessels

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 197 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03644043 unknown statusnot on this mapstarted 2018, after this paper: background citation

Quantitative EEG for Assessment of Mild Cognitive Impairment Associated With Preclinical Alzheimer's Disease - Evidence for Amyloid Indication Study

Typeobservational_patient_registrySponsorMetabolic Therapy Inc.Ran2018 to 2020Enrolled2,000ConditionsAlzheimer Disease, Dementia Frontal, Mild Cognitive ImpairmentArmsEEG scan
NCT05869032 unknown statusnot on this mapstarted 2023, after this paper: background citation

Establishing Normative Values for Event Related Potentials (ERPs) and Quantitative EEG (QEEG) in Adult, Healthy Volunteers

TypeobservationalSponsorNeuronetrix, Inc.Ran2023 to 2024Enrolled80ConditionsHealthy
3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic.Autism research : official journal of the International Society for Autism Research · 2025
    Pooled it
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  6. P300 Measures and Drive-Related Risks: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Is COPD associated with alterations in hearing? A systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease
    Pooled it
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  12. Effects ofNutrients · 2023
    Trial
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  16. The effects of an internet-based mindfulness meditation intervention on electrophysiological markers of attention.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020
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  19. Article
  20. Article

137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rik van DinterenResearch Institute Brainclinics, Nijmegen, The Netherlands ; Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
Martijn ArnsResearch Institute Brainclinics, Nijmegen, The Netherlands ; Utrecht University, Department of Experimental Psychology, Nijmegen, The Netherlands.
Marijtje L A JongsmaBehavioral Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Roy P C KesselsDonders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands ; Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe P300 component of the event-related potential is a large positive waveform that can be extracted from the ongoing electroencephalogram using a two-stimuli oddball paradigm, and has been associated with cognitive information processing (e.g. memory, attention, executive function). This paper reviews the development of the auditory P300 across the lifespan. METHODOLOGY/PRINCIPAL

findingsA systematic review and meta-analysis on the P300 was performed including 75 studies (n = 2,811). Scopus was searched for studies using healthy subjects and that reported means of P300 latency and amplitude measured at Pz and mean age. These findings were validated in an independent, existing cross-sectional dataset including 1,572 participants from ages 6-87. Curve-fitting procedures were applied to obtain a model of P300 development across the lifespan. In both studies logarithmic Gaussian models fitted the latency and amplitude data best. The P300 latency and amplitude follow a maturational path from childhood to adolescence, resulting in a period that marks a plateau, after which degenerative effects begin. We were able to determine ages that mark a maximum (in P300 amplitude) or trough (in P300 latency) segregating maturational from degenerative stages. We found these points of deflection occurred at different ages. CONCLUSIONS/SIGNIFICANCE: It is hypothesized that latency and amplitude index different aspects of brain maturation. The P300 latency possibly indexes neural speed or brain efficiency. The P300 amplitude might index neural power or cognitive resources, which increase with maturation.

Indexed as

AdolescentAdultAgedAged, 80 and overAgingAttentionBrainChildCognitionCross-Sectional StudiesElectroencephalographyEvent-Related Potentials, P300Executive FunctionFemaleHumansMale

Identifiers

PMID24551055
PMCPMC3923761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.